Inhibitory effects of huperzine B on cholinesterase activity in mice
文献类型：期刊论文
| 作者 | Liu, J ; Zhang, HY; Wang, LM; Tang, XC
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-02 |
| 卷号 | 20期号:2页码:141-145 |
| 关键词 | huperzine B tacrine cholinesterase inhibitors cholinesterases acetylcholinesterase brain cerebral cortex |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To determine the anticholinesterase properties of huperzine B (Hup B) and compare with tacrine in vitro and in vivo. METHODS: Spectrophotometry was used to determine ChE activity. RESULTS: Hup B showed much more selective inhibition to acetylcholinesterase (AChE) than tacrine. The IC50 ratios of Hup B and tacrine for butyrylcholinesterase (BuChE): AChE were 65.8 and 0.54, respectively. Hup B ig exhibited higher efficacy on the inhibition of brain AChE than that of tacrine. Tacrine was more effective in the inhibition of serum BuChE in mice with severe concomitant peripheral adverse effects than Hup B. A single ig dose of Hup B produced steady state of AChE inhibition in 4 h. CONCLUSION: Hup B exhibits higher selectivity and efficacy in the inhibition of AChE, and lower toxicity in mice than tacrine. |
| WOS关键词 | ALZHEIMERS-DISEASE ; TACRINE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000078533100010 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274755]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 分析化学研究室 上海药物代谢研究中心 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, J,Zhang, HY,Wang, LM,et al. Inhibitory effects of huperzine B on cholinesterase activity in mice[J]. ACTA PHARMACOLOGICA SINICA,1999,20(2):141-145. |
| APA | Liu, J,Zhang, HY,Wang, LM,&Tang, XC.(1999).Inhibitory effects of huperzine B on cholinesterase activity in mice.ACTA PHARMACOLOGICA SINICA,20(2),141-145. |
| MLA | Liu, J,et al."Inhibitory effects of huperzine B on cholinesterase activity in mice".ACTA PHARMACOLOGICA SINICA 20.2(1999):141-145. |
入库方式： OAI收割
来源：上海药物研究所
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