Quantum chemical investigation on solvation of Ginkgolides
文献类型：期刊论文
| 作者 | Chen, JZ; Chen, KX ; Jiang, HL; Gu, JD; Zhu, WL; Hu, ZJ; Ji, RY
|
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 1998-10 |
| 卷号 | 41期号:5页码:494-503 |
| ISSN号 | 1006-9291 |
| 关键词 | ginkgolides solvation quantum chemistry PLS |
| DOI | 10.1007/BF02882803 |
| 文献子类 | Article |
| 英文摘要 | Great attention has been paid to ginkgolides in modern medical science due to their special medicinal functions. Ginkgolides can be used to treat asthma and tracheitis, etc. Pharmacological studies indicated that ginkgolides are potent antagonists of platelet activating factor (PAF). We have calculated the molecular structures and electronic structures of ginkgolides in hexadecane solution and aqueous solution with AM1-SM1 method. The results provided a model of hydrophobicity and hydrogen bonds for ginkgolides interacting with PAF. |
| WOS关键词 | MODEL |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000076532000007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274803]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Jiang, HL |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, JZ,Chen, KX,Jiang, HL,et al. Quantum chemical investigation on solvation of Ginkgolides[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,1998,41(5):494-503. |
| APA | Chen, JZ.,Chen, KX.,Jiang, HL.,Gu, JD.,Zhu, WL.,...&Ji, RY.(1998).Quantum chemical investigation on solvation of Ginkgolides.SCIENCE IN CHINA SERIES B-CHEMISTRY,41(5),494-503. |
| MLA | Chen, JZ,et al."Quantum chemical investigation on solvation of Ginkgolides".SCIENCE IN CHINA SERIES B-CHEMISTRY 41.5(1998):494-503. |
入库方式： OAI收割
来源：上海药物研究所
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