Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance
文献类型：期刊论文
| 作者 | Liu, J ; Zhang, HY; Tang, XC; Wang, B; He, XC; Bai, DL
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1998-09 |
| 卷号 | 19期号:5页码:413-416 |
| 关键词 | cholinesterase inhibitors cholinesterases huperzine A cerebral cortex erythrocyte membrane scopolamine memory maze learning |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To compare the effects of synthetic and natural (-)-huperzine A (Hup A) on cholinesterase and mouse water maze performance. METHODS: Spectrophotometry was used to determine cholinesterase activity. Mouse water maze was used to evaluate nootropic effect. RESULTS: The IC50 of synthetic Hup A for acetylcholinesterase (AChE) of rat cortex and rat erythrocyte membrane determined in vitro were 64.7 (52.6 - 79.5) and 53.9 (43.6 - 66.6) nmol . L-1, respectively, and for butyrylcholinesterase of rat serum was 53.6 (44.9 - 63.8) mu mol.L-1. Synthetic Hup A 0.12 - 0.48 mg. kg(-1) ig produced a dose-dependent inhibition of brain AChE in mice. Synthetic Hup A 0.05 mg: kg(-1) ig attenuated scopolamine-induced impairment of spatial memory. The efficacy of synthetic Hup A was the same as natural Hup A. CONCLUSION: Synthetic Hup A yielded an in. vitro and in vivo pharmacological profile of activities similar to that of natural Hup A. |
| WOS关键词 | HUPERZINE-A ; ALZHEIMERS-DISEASE ; MEMORY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000075784800004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274806]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Tang, XC |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Synthet Chem, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, J,Zhang, HY,Tang, XC,et al. Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance[J]. ACTA PHARMACOLOGICA SINICA,1998,19(5):413-416. |
| APA | Liu, J,Zhang, HY,Tang, XC,Wang, B,He, XC,&Bai, DL.(1998).Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance.ACTA PHARMACOLOGICA SINICA,19(5),413-416. |
| MLA | Liu, J,et al."Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance".ACTA PHARMACOLOGICA SINICA 19.5(1998):413-416. |
入库方式： OAI收割
来源：上海药物研究所
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