Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine
文献类型：期刊论文
| 作者 | Wang, T; Tang, XC
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 1998-05-22 |
| 卷号 | 349期号:2-3页码:137-142 |
| 关键词 | acetylcholinesterase inhibitor (-)-huperzine A E2020 tacrine Alzheimer's disease radial maze memory (rat) |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/S0014-2999(98)00199-X |
| 文献子类 | Article |
| 英文摘要 | The effects of ( -)-huperzine A ((5R,9R,11 E)-5-amino-11-ethylidene- 5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one), and of the hydrochloride salt of E2020 ((R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methyl piperidine) and tacrine (9-amino-1,2,3,4-tetrahydroacridine), on the scopolamine-induced memory deficits in rats were compared in a radial maze, using a 4-out-of-8 baiting procedure. Scopolamine (0.15 mg/kg, i.p.) caused significant impairment in the rats' ability to fulfil the radial maze task. (-)-Huperzine A (0.2-0.4 mg/kg, p.o.; 0.1-0.4 mg/kg, i.p.) had greater efficacy than E2020 (0.6-0.9 mg/kg, p.o.; 0.3-0.6 mg/kg, i.p.) and tacrine (1.5-2.5 mg/kg, p.o.; 0.3-0.6 mg/kg, i.p.) on the improvement of scopolamine-induced working and reference memory errors, respectively. There appeared to be an inverse bell-shape dose-dependent effect for all three compounds tested. The compared data demonstrate that (-)-huperzine A is the most potent and orally active acetylcholinesterase inhibitor of the three, and fits more closely the established criterions for an ideal acetylcholinesterase inhibitor to be used in clinical studies. (C) 1998 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | ALZHEIMERS-DISEASE ; REFERENCE MEMORY ; WORKING ; RATS ; DRUG |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000074286800001 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274837]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第三研究室 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, T,Tang, XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,1998,349(2-3):137-142. |
| APA | Wang, T,&Tang, XC.(1998).Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.EUROPEAN JOURNAL OF PHARMACOLOGY,349(2-3),137-142. |
| MLA | Wang, T,et al."Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine".EUROPEAN JOURNAL OF PHARMACOLOGY 349.2-3(1998):137-142. |
入库方式： OAI收割
来源：上海药物研究所
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