Anticholinesterase effects of huperzine A, E2020, and tacrine in rats
文献类型：期刊论文
| 作者 | Wang, H; Tang, XC
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1998-01 |
| 卷号 | 19期号:1页码:27-30 |
| 关键词 | cholinesterase inhibitors cholinesterases huperzine A E2020 tacrine |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To compare the anticholinesterase effects of huperzine A (Hup A), E2020, and tacrine in rats. METHODS: Spectrophotometry was used to determine AChE activity in brain and BuChE activity in serum. RESULTS: Following intragastric gavage, Hup A, E2020, and tacrine all produced dose-dependent inhibitions of brain AChE. Oral Hup A exhibited a higher inhibition than E2020 and tacrine. Tacrine was more effective in inhibiting serum BuChE correlated with severe peripheral adverse effects. The BuChE activity was less affected by Hup A and E2020. After a single oral dose of Hup A, a relatively steady state of AChE inhibition produced, which was longer than that after E2020 and tacrine. No change in the cholinesterase inhibition was seen for the 3 drugs following repeated ig medications. CONCLUSION: Hup A ig exhibited a higher efficacy, a longer duration of action, and a more selective inhibition on AChE than E2020 and tacrine. |
| WOS关键词 | ALZHEIMERS-DISEASE ; PHYSOSTIGMINE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000071424500007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274866]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, H,Tang, XC. Anticholinesterase effects of huperzine A, E2020, and tacrine in rats[J]. ACTA PHARMACOLOGICA SINICA,1998,19(1):27-30. |
| APA | Wang, H,&Tang, XC.(1998).Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.ACTA PHARMACOLOGICA SINICA,19(1),27-30. |
| MLA | Wang, H,et al."Anticholinesterase effects of huperzine A, E2020, and tacrine in rats".ACTA PHARMACOLOGICA SINICA 19.1(1998):27-30. |
入库方式： OAI收割
来源：上海药物研究所
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