Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro
文献类型：期刊论文
| 作者 | Lin, JH; Hu, GY; Tang, XC
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1997-01 |
| 卷号 | 18期号:1页码:6-10 |
| 关键词 | cholinesterase inhibitors huperzine A tacrine E2020 neuromuscular junction diaphragm phrenic nerve electrophysiology |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To compare the effects of huperzine A (Hup A), tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro. METHODS: The isolated mouse phrenic nerve-hemidiaphragm preparations were used with the conventional intracellular recording technique. The miniature end-plate potentials (MEPP), the mean quantal content of end-plate potentials (EPP), and the resting membrane potentials of muscle fiber were recorded. RESULTS: Hup A, tacrine, and E2020 at the concentration of 1.0 mu mol . L(-1) increased the amplitude, time-to-peak, and half-decay time of MEPP in the potencies of E2020 > Hup A > tacrine. Hup A did not significantly change the frequency of MEPP, the appearance of giant MEPP or slow MEPP, the resting membrane potentials, and the mean quantal content of EPP. CONCLUSION: Hup A is a selective and potent cholinesterase inhibitor, by which activity it facilitates the cholinergic transmission at mouse neuromuscular junction, and devoid of pre- and post-synaptic actions. |
| WOS关键词 | QUANTAL RELEASE ; ACETYLCHOLINE ; INHIBITOR ; COGNITION ; SYSTEM |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997WB88800002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274935]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,STATE KEY LAB DRUG RES,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Lin, JH,Hu, GY,Tang, XC. Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro[J]. ACTA PHARMACOLOGICA SINICA,1997,18(1):6-10. |
| APA | Lin, JH,Hu, GY,&Tang, XC.(1997).Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro.ACTA PHARMACOLOGICA SINICA,18(1),6-10. |
| MLA | Lin, JH,et al."Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro".ACTA PHARMACOLOGICA SINICA 18.1(1997):6-10. |
入库方式： OAI收割
来源：上海药物研究所
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