Huperzine A, a novel promising acetylcholinesterase inhibitor
文献类型：期刊论文
| 作者 | Cheng, DH; Ren, H; Tang, XC
|
| 刊名 | NEUROREPORT
 |
| 出版日期 | 1996-12-20 |
| 卷号 | 8期号:1页码:97-101 |
| 关键词 | Alzheimer's disease cholinesterase inhibitor E2020 huperzine A memory radial maze scopolamine tacrine |
| ISSN号 | 0959-4965 |
| DOI | 10.1097/00001756-199612200-00020 |
| 文献子类 | Article |
| 英文摘要 | THE effects of huperzine A on memory impairments induced by scopolamine were evaluted using a radial maze task and inhibition of cholinesterase in vitro compared with the effects of E2020 and tacrine. Scopolamine (0.2 mg kg(-1)) significantly impaired spatial memory in rats. Huperzine A (0.1-0.4 mg kg(-1), p.o.), E2020 (0.5-1.0 mg kg(-1), p.o.) and tacrine (1.0-2.0 mg kg(-1), p.o) could reverse these scopolamine-induced memory deficits. The ratios of huperzine A, E2020 and tacrine for butyrylcholinesterase:acetylcholinesterase determined by a colourimetric method were 884.57, 489.05, and 0.80, respectively. The results demonstrated that huperzine A was the most selective acetylcholinterase inhibitor, and improved the working memory deficit induced by scopolamine significantly better than did E2020 or tacrine, suggesting it may be a promising agent for clinical therapy of cognitive impairment in patients with Alzheimer's Disease. |
| WOS关键词 | ALZHEIMERS-DISEASE ; SENILE DEMENTIA ; MEMORY ; ABNORMALITIES ; SYSTEM ; RAT |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:A1996WX33900021 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274943]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 作者单位 | CHINESE ACAD SCI, SHANGHAI INST MAT MED, STATE KEY LAB DRUG RES, SHANGHAI 200031, PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Cheng, DH,Ren, H,Tang, XC. Huperzine A, a novel promising acetylcholinesterase inhibitor[J]. NEUROREPORT,1996,8(1):97-101. |
| APA | Cheng, DH,Ren, H,&Tang, XC.(1996).Huperzine A, a novel promising acetylcholinesterase inhibitor.NEUROREPORT,8(1),97-101. |
| MLA | Cheng, DH,et al."Huperzine A, a novel promising acetylcholinesterase inhibitor".NEUROREPORT 8.1(1996):97-101. |
入库方式： OAI收割
来源：上海药物研究所
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