中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro

文献类型:期刊论文

作者Lin, JH; Hu, GY; Tang, XC
刊名ACTA PHARMACOLOGICA SINICA
出版日期1996-07
卷号17期号:4页码:299-301
关键词cholinesterase inhibitors huperzine-A tacrine E2020 neuromuscular junction diaphragm phrenic nerve electrophysiology
ISSN号0253-9756
文献子类Article
英文摘要AIM: To study the effects of huperzine-A on neuromuscular junction transmission in mouse. METHODS: The isolated mouse phrenic nerve-hemidiaphragm preparations were used with the conventional intracellular recording technique. The spontaneous electrical activities of cholinergic nerve terminals (miniature end-plate potentials, MEPP) were recorded. RESULTS: Huperzine-A, tacrine, and E2020 at the concentrations of 0.05-1 mu mol . L(-1) increased the amplitude, mean rise time, and half decay time of MEPP in a concentration-dependent manner. Their potencies were E2020 > huperzine-A > tacrine. CONCLUSION: The anticholinesterase action of huperzine-A in cholinergic synapses is stronger than that of tacrine.
WOS关键词CENTRAL CHOLINERGIC SYSTEM ; CHOLINESTERASE INHIBITOR ; PHYSOSTIGMINE ; ACETYLCHOLINE ; RAT
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
CSCD记录号CSCD:339757
WOS记录号WOS:A1996UW39400003
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/274966]  
专题院士及顾问专家
中科院受体结构与功能重点实验室
新药研究国家重点实验室
作者单位CHINESE ACAD SCI,SHANGHAI INST MAT MED,STATE KEY LAB DRUG RES,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式
GB/T 7714
Lin, JH,Hu, GY,Tang, XC. Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro[J]. ACTA PHARMACOLOGICA SINICA,1996,17(4):299-301.
APA Lin, JH,Hu, GY,&Tang, XC.(1996).Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro.ACTA PHARMACOLOGICA SINICA,17(4),299-301.
MLA Lin, JH,et al."Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro".ACTA PHARMACOLOGICA SINICA 17.4(1996):299-301.

入库方式: OAI收割

来源:上海药物研究所

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