Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro
文献类型：期刊论文
| 作者 | Lin, JH; Hu, GY; Tang, XC
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1996-07 |
| 卷号 | 17期号:4页码:299-301 |
| 关键词 | cholinesterase inhibitors huperzine-A tacrine E2020 neuromuscular junction diaphragm phrenic nerve electrophysiology |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effects of huperzine-A on neuromuscular junction transmission in mouse. METHODS: The isolated mouse phrenic nerve-hemidiaphragm preparations were used with the conventional intracellular recording technique. The spontaneous electrical activities of cholinergic nerve terminals (miniature end-plate potentials, MEPP) were recorded. RESULTS: Huperzine-A, tacrine, and E2020 at the concentrations of 0.05-1 mu mol . L(-1) increased the amplitude, mean rise time, and half decay time of MEPP in a concentration-dependent manner. Their potencies were E2020 > huperzine-A > tacrine. CONCLUSION: The anticholinesterase action of huperzine-A in cholinergic synapses is stronger than that of tacrine. |
| WOS关键词 | CENTRAL CHOLINERGIC SYSTEM ; CHOLINESTERASE INHIBITOR ; PHYSOSTIGMINE ; ACETYLCHOLINE ; RAT |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:339757 |
| WOS记录号 | WOS:A1996UW39400003 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274966]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,STATE KEY LAB DRUG RES,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Lin, JH,Hu, GY,Tang, XC. Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro[J]. ACTA PHARMACOLOGICA SINICA,1996,17(4):299-301. |
| APA | Lin, JH,Hu, GY,&Tang, XC.(1996).Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro.ACTA PHARMACOLOGICA SINICA,17(4),299-301. |
| MLA | Lin, JH,et al."Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro".ACTA PHARMACOLOGICA SINICA 17.4(1996):299-301. |
入库方式： OAI收割
来源：上海药物研究所
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