The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives
文献类型：期刊论文
| 作者 | Wang, Jing1; Yang, Teng2,3; Chen, Huang4,5; Xu, Yun-Nan1; Yu, Li-Fang1; Liu, Ting1; Tang, Jie1,6; Yi, Zhengfang4,5; Yang, Cai-Guang3 ; Xue, Wei2
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| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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| 出版日期 | 2017-02-15 |
| 卷号 | 127页码:424-433 |
| 关键词 | Berberine derivatives Antistaphylococcal activity Multidrug-resistant Cytotoxicity |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2017.01.012 |
| 文献子类 | Article |
| 英文摘要 | A series of novel 9, 13-disubstituted berberine derivatives have been synthesized and evaluated for the antibacterial activities against Staphylococcus aureus, including Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). Compound 20 shows the most potent activity against the growth of Newman strain, with a MIC value of 0.78 mu g/mL, which is comparable with the positive control vancomycin. In addition, compound 20, 21, and 33 are highly antistaphylococcal active against five strains of multidrug-resistant S. aureus, with MIC values of 0.78-1.56 mu g/mL. Of note, theses antibacterial active compounds have no obvious toxicity to the viability of human fibroblast (HAF) cells at the MIC concentration. (C) 2017 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | RESISTANT STAPHYLOCOCCUS-AUREUS ; HUMAN SERUM-ALBUMIN ; MULTIFUNCTIONAL AGENTS ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; BIOLOGICAL EVALUATION ; ALZHEIMERS-DISEASE ; NATURAL-PRODUCT ; IN-VITRO ; HYBRIDS |
| 资助项目 | National Key Technology RD Program[2015BAK45B00] ; National Natural Science Foundation of China[81472788] ; National Natural Science Foundation of China[81272463] ; National Natural Science Foundation of China[81661138004] ; Major State Basic Research Development Program of China[2015CB910400] ; Shanghai Science and Technology Council[14DZ0511800] ; Shanghai Science and Technology Council[14142201200] ; Laboratory of Organic Functional Molecules, Sino-French Institute of ECNU[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000397172800035 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275629]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xue, Wei; Yang, Fan |
| 作者单位 | 1.East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, SCME, Shanghai 200062, Peoples R China; 2.Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Ctr Res & Dev Fine Chem, Minist Educ, Guiyang 550225, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Shanghai 200241, Peoples R China; 5.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China; 6.East China Normal Univ, SCME, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Yang, Teng,Chen, Huang,et al. The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017,127:424-433. |
| APA | Wang, Jing.,Yang, Teng.,Chen, Huang.,Xu, Yun-Nan.,Yu, Li-Fang.,...&Yang, Fan.(2017).The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,127,424-433. |
| MLA | Wang, Jing,et al."The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 127(2017):424-433. |
入库方式： OAI收割
来源：上海药物研究所
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