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Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage

文献类型：期刊论文

作者Huang, Xing-Hao1,2,4; Tao, Ling-Xue3; Ke, Chang-Qiang1,2; Tang, Chunping1,2; Zhang, Hai-Yan3; Ye, Yang1,2,5; Lin, Li-Gen6; Yao, Sheng1,2
刊名ORGANIC LETTERS
出版日期2017-02-03
卷号19期号:3页码:556-559
ISSN号1523-7060
DOI10.1021/acs.orglett.6b03597
文献子类Article
英文摘要Two dimeric diterpenoids, taxodikaloids A (1) and B (2), have been identified from the seeds of Taxodium ascendens. The diterpenoid structures were established on the basis of comprehensive spectroscopic analysis, and the absolute configuration of taxodikaloid A (1) was further confirmed by single-crystal X-ray diffraction. Both structures feature an unprecedented oxazoline ring linkage connecting two abietane diterpenoid monomers. A plausible biosynthetic pathway for compounds 1 and 2 is proposed. Both compounds show potential neuroprotective activity against A beta(25-35)-induced damage in SH-SY5Y cells.
WOS关键词TAIWANIA CRYPTOMERIOIDES ; ALZHEIMERS-DISEASE ; SH-SY5Y CELLS ; FORMOSANA ; BARK ; CYCLOADDUCTS ; HEARTWOOD ; JAPONICA ; INJURY
资助项目National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Foundation of China[81302657] ; National Natural Science Foundation of China[81473112] ; National Natural Science Foundation of China[81573305] ; National Natural Science Foundation of China[81673327] ; Chinese Academy of Sciences[KSZD-EW-Z-004-01] ; State Key Laboratory of Drug Research[SIMM1501ZZ-03] ; Science and Technology Development Fund of Macau[FCDT 120/2013/A3] ; Research Fund of University of Macau[MYRG2014-00020-ICMS-QRCM] ; Research Fund of University of Macau[MYRG2015-00153-ICMS-QRCM]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000393539900033
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/275637]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Lin, Li-Gen; Yao, Sheng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China;
6.Univ Macau, Inst Chinese Med Sci, Key Lab Qual Res Chinese Med, Macau, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Xing-Hao,Tao, Ling-Xue,Ke, Chang-Qiang,et al. Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage[J]. ORGANIC LETTERS,2017,19(3):556-559.
APA Huang, Xing-Hao.,Tao, Ling-Xue.,Ke, Chang-Qiang.,Tang, Chunping.,Zhang, Hai-Yan.,...&Yao, Sheng.(2017).Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage.ORGANIC LETTERS,19(3),556-559.
MLA Huang, Xing-Hao,et al."Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage".ORGANIC LETTERS 19.3(2017):556-559.

入库方式： OAI收割

来源：上海药物研究所

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