A small-molecule inhibitor of NF-kappa B-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury
文献类型：期刊论文
| 作者 | Ren, Xiaomeng1; Li, Xinzhi1; Jia, Linna1; Chen, Deheng2; Hou, Hai3; Rui, Liangyou4; Zhao, Yujun2 ; Chen, Zheng1
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| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2017-02 |
| 卷号 | 31期号:2页码:711-718 |
| 关键词 | NIK liver injury inflammation CCl4 |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.201600840R |
| 文献子类 | Article |
| 英文摘要 | Potent and selective chemical probes are valuable tools for discovery of novel treatments for human diseases. NF-B-inducing kinase (NIK) is a key trigger in the development of liver injury and fibrosis. Whether inhibition of NIK activity by chemical probes ameliorates liver inflammation and injury is largely unknown. In this study, a small-molecule inhibitor of NIK, B022, was found to be a potent and selective chemical probe for liver inflammation and injury. B022 inhibited the NIK signaling pathway, including NIK-induced p100-to-p52 processing and inflammatory gene expression, both in vitro and in vivo. Furthermore, in vivo administration of B022 protected against not only NIK but also CCl4-induced liver inflammation and injury. Our data suggest that inhibition of NIK is a novel strategy for treatment of liver inflammation, oxidative stress, and injury.-Ren, X., Li, X., Jia, L., Chen, D., Hou, H., Rui, L., Zhao, Y., Chen, Z. A small-molecule inhibitor of NF-kappa B-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury. |
| WOS关键词 | REGULATES GLUCOSE-METABOLISM ; CARBON-TETRACHLORIDE ; HEPATIC-FIBROSIS ; INSULIN-RESISTANCE ; SIGNALING PATHWAY ; IKK-ALPHA ; RAT-LIVER ; ACTIVATION ; MICE ; EXPRESSION |
| 资助项目 | Changbai Mountain Scholars Program of The People's Government of Jilin Province Grant[2013046] ; Jilin Science and Technology Development Program Grant[20160101204JC] ; Jilin Talent Development Foundation Grant[111860000] ; Fok Ying Tong Education Foundation Grant[151022] ; National Natural Science Foundation of China Grants[31500957] ; National Natural Science Foundation of China Grants[31671225] ; startup funds from Northeast Normal University[120401204] ; Shanghai Institute of Materia Medica startup grant[00000000] ; Young Overseas High-Level Talents Introduction Plan from the Chinese government[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000394235400023 |
| 出版者 | FEDERATION AMER SOC EXP BIOL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275641]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Yujun; Chen, Zheng |
| 作者单位 | 1.Northeast Normal Univ, Sch Life Sci, Key Lab Mol Epigenet, Minist Educ, Changchun, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Met Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Bioscience & Biotechnol, Xian, Peoples R China; 4.Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA |
| 推荐引用方式 GB/T 7714 | Ren, Xiaomeng,Li, Xinzhi,Jia, Linna,et al. A small-molecule inhibitor of NF-kappa B-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury[J]. FASEB JOURNAL,2017,31(2):711-718. |
| APA | Ren, Xiaomeng.,Li, Xinzhi.,Jia, Linna.,Chen, Deheng.,Hou, Hai.,...&Chen, Zheng.(2017).A small-molecule inhibitor of NF-kappa B-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury.FASEB JOURNAL,31(2),711-718. |
| MLA | Ren, Xiaomeng,et al."A small-molecule inhibitor of NF-kappa B-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury".FASEB JOURNAL 31.2(2017):711-718. |
入库方式： OAI收割
来源：上海药物研究所
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