Diterpenoids and Lignans from Cephalotaxus fortunei
文献类型：期刊论文
| 作者 | Zhao, Jin-Xin1; Fan, Yao-Yue1; Xu, Jin-Biao1; Gan, Li-She2; Xu, Cheng-Hui1; Ding, Jian1 ; Yue, Jian-Min1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2017-02 |
| 卷号 | 80期号:2页码:356-362 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.6b00802 |
| 文献子类 | Article |
| 英文摘要 | Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) by X-ray crystallographic data. Compounds 3 and 4 are the first examples of 17-nor-cephalotane-type diterpenoids that are likely the biosynthesis precursors of the co-occurring troponoids (e.g., 1, 2, and 9). Compound 1 exhibited cytotoxic activities against HL-60 and A-549 cells with IC50 values of 0.77 +/- 0.05 and 1.129 +/- 0.057 mu M, respectively. |
| WOS关键词 | NATURAL-PRODUCTS ; K KOCH ; ALKALOIDS ; HARRINGTONOLIDE ; DRUPACEA ; TUMOR |
| 资助项目 | National Natural Science Foundation of the People's Republic of China[21532007] ; National Natural Science Foundation of the People's Republic of China[U1302222] ; National Natural Science Foundation of the People's Republic of China[81321092] ; project "Personalized Medicines-Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020321] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000395046900015 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275648]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Jin-Xin,Fan, Yao-Yue,Xu, Jin-Biao,et al. Diterpenoids and Lignans from Cephalotaxus fortunei[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(2):356-362. |
| APA | Zhao, Jin-Xin.,Fan, Yao-Yue.,Xu, Jin-Biao.,Gan, Li-She.,Xu, Cheng-Hui.,...&Yue, Jian-Min.(2017).Diterpenoids and Lignans from Cephalotaxus fortunei.JOURNAL OF NATURAL PRODUCTS,80(2),356-362. |
| MLA | Zhao, Jin-Xin,et al."Diterpenoids and Lignans from Cephalotaxus fortunei".JOURNAL OF NATURAL PRODUCTS 80.2(2017):356-362. |
入库方式： OAI收割
来源：上海药物研究所
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