Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis
文献类型：期刊论文
| 作者 | Zhang, Shuwei1; Qiu, Yixin1,2,3; Kakule, Thomas B.4; Lu, Zhenyu5; Xu, Fuchao1; Lamb, John G.5; Reilly, Christopher A.5; Zheng, Yong6; Sham, Shing Wo Simon7; Wang, Wei2,3 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2017-02 |
| 卷号 | 80期号:2页码:363-370 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.6b00808 |
| 文献子类 | Article |
| 英文摘要 | Seven cyclic depsipeptides were isolated from Hapsidospora irregularis and structurally characterized as the calcium channel blocker leualacin and six new analogues based on the NMR and HRESIMS data. These new compounds were named leualacins B-G. The absolute configurations of the amino acids and 2-hydroxyisocaproic acids were determined by recording the optical rotation values. Biological studies showed that calcium influx elicited by leualacin F in primary human lobar bronchial epithelial cells involves the TRPA1 channel. Through genome sequencing and targeted gene disruption, a noniterative nonribosomal peptide synthetase was found to be involved in the biosynthesis of leualacin. A comparison of the structures of leualacin and its analogues indicated that the A(2) and A(4) domains of the leualacin synthetase are substrate specific, while A(1), A(3), and A(5) can accept alternative precursors to yield new molecules. |
| WOS关键词 | CALCIUM BLOCKER ; TRPA1 ; ACIDS ; INFLAMMATION ; DERIVATIVES ; LEUALACIN ; PEPTIDES ; LEUCINE |
| 资助项目 | Utah State University SPARC grant[00000000] ; National Science Foundation Award[CHE-1429195] ; NIH[ES017431] ; NIH[GM107557] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000395046900016 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275649]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wei; Zhan, Jixun |
| 作者单位 | 1.Utah State Univ, Dept Biol Engn, 4105 Old Main Hill, Logan, UT 84322 USA; 2.Hunan Univ Chinese Med, Sch Pharm, TCM, Changsha 410208, Hunan, Peoples R China; 3.Hunan Univ Chinese Med, Sch Pharm, Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China; 4.Univ Utah, Dept Med Chem, LS Skaggs Pharm Inst, Salt Lake City, UT 84112 USA; 5.Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA; 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 202203, Peoples R China; 7.Utah State Univ, Dept Chem & Biochem, 0300 Old Main Hill, Logan, UT 84322 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Shuwei,Qiu, Yixin,Kakule, Thomas B.,et al. Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(2):363-370. |
| APA | Zhang, Shuwei.,Qiu, Yixin.,Kakule, Thomas B..,Lu, Zhenyu.,Xu, Fuchao.,...&Zhan, Jixun.(2017).Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis.JOURNAL OF NATURAL PRODUCTS,80(2),363-370. |
| MLA | Zhang, Shuwei,et al."Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis".JOURNAL OF NATURAL PRODUCTS 80.2(2017):363-370. |
入库方式： OAI收割
来源：上海药物研究所
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