The Spatio-Temporal Expression Profiles of CD4+T Cell Differentiation and Function-Related Genes During EAE Pathogenesis
文献类型：期刊论文
| 作者 | Cai, Yingying1; Shen, Hu2; Qin, Chaoyan1; Zhou, Jinfeng1; Lai, Weiming1; Pan, Juping2; Du, Changsheng1,3 |
| 刊名 | INFLAMMATION
 |
| 出版日期 | 2017-02 |
| 卷号 | 40期号:1页码:195-204 |
| 关键词 | cytokine experimental autoimmune encephalomyelitis multiple sclerosis transcription factor |
| ISSN号 | 0360-3997 |
| DOI | 10.1007/s10753-016-0469-1 |
| 文献子类 | Article |
| 英文摘要 | Multiple sclerosis is a CD4(+) T cell-mediated autoimmune disease of the central nervous system. The unbalance of the cytokines and transcription factors critical for CD4(+) T cell differentiation and function is probably the main reason that causes MS. We detected the mRNA expression changes of key cytokines and transcription factors which are critical for Th1, Th2, Th17, and Treg cell differentiation and function in different tissues during EAE pathogenesis. We fund that each gene not only has its own featured expression changes, but also has interaction with one another, which composes a network of immunity. Understanding the roles of key cytokines and transcription factors in these processes will help to understand disease pathogenesis and supply indications for disease therapy. |
| WOS关键词 | REGULATORY T-CELLS ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; TGF-BETA ; MULTIPLE-SCLEROSIS ; TH17 CELLS ; INFLAMMATION ; CYTOKINE ; RECEPTOR ; IL-10 ; BRAIN |
| 资助项目 | Ministry of Science and Technology of China[2014CB541903] ; Ministry of Science and Technology of China[2012CB910404] ; National Natural Science Foundation of China[31171348] ; National Natural Science Foundation of China[31371414] ; Shanghai Municipal Education Commission[14zz042] ; State Key Laboratory of Drug Research[SIMM1302KF-09] ; Fundamental Research Funds for the Central Universities[00000000] |
| WOS研究方向 | Cell Biology ; Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000393655500020 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275652]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Pan, Juping; Du, Changsheng |
| 作者单位 | 1.Tongji Univ, Res Ctr Translat Med, Shanghai Key Lab Signaling & Dis Res, East Hosp,Sch Life Sci & Technol, 1239 Si Ping Rd, Shanghai 200092, Peoples R China; 2.Tongji Univ, Tongji Hosp, Tongji Univ Branch, 1239 Si Ping Rd, Shanghai 200092, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Yingying,Shen, Hu,Qin, Chaoyan,et al. The Spatio-Temporal Expression Profiles of CD4+T Cell Differentiation and Function-Related Genes During EAE Pathogenesis[J]. INFLAMMATION,2017,40(1):195-204. |
| APA | Cai, Yingying.,Shen, Hu.,Qin, Chaoyan.,Zhou, Jinfeng.,Lai, Weiming.,...&Du, Changsheng.(2017).The Spatio-Temporal Expression Profiles of CD4+T Cell Differentiation and Function-Related Genes During EAE Pathogenesis.INFLAMMATION,40(1),195-204. |
| MLA | Cai, Yingying,et al."The Spatio-Temporal Expression Profiles of CD4+T Cell Differentiation and Function-Related Genes During EAE Pathogenesis".INFLAMMATION 40.1(2017):195-204. |
入库方式： OAI收割
来源：上海药物研究所
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