Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents
文献类型：期刊论文
| 作者 | Wang, Chang-Zheng1,2; Chen, Jia-Li1,2,4; Tang, Ying3; Zang, Yi4 ; Chen, Guo-Rong1,2; James, Tony D.5; Li, Jia4; Wu, Changfeng3; He, Xiao-Peng1,2
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2017-02-01 |
| 卷号 | 9期号:4页码:3272-3276 |
| 关键词 | polymer dot glycoprobe cell imaging ratiometric probe |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.6b14249 |
| 文献子类 | Article |
| 英文摘要 | A supramolecular, polymer-dot-based ensemble has been developed for the ratiometric detection of lectins and targeted delivery of glycoprobes. Self-assembly between a blue-emitting polymer dot and a red-emitting glycoprobe, results in an ensemble that shows red emission upon excitation of the polymer dot because of Forster resonance energy transfer. Resulting in ratiometric detection of lectins in buffer solution as well as targeted delivery of the glycoprobe to cells that highly express a sugar receptor. Unlike conventional systems where both the agent and vector are codelivered intracellularly, our ensemble developed here shows a receptor-controlled dissociation on the cell membrane. |
| WOS关键词 | CLICK CHEMISTRY ; RECEPTOR ; NANOPARTICLES ; FLUORESCENCE ; THERANOSTICS ; PROTEINS ; CELLS ; RECOGNITIONS ; GLYCOPROBES ; ULTRABRIGHT |
| 资助项目 | 973 project[2013CB733700] ; Science and Technology Commission of Shanghai Municipality[15540723800] ; Natural Science Foundation of China[21572058] ; Natural Science Foundation of China[21576088] ; Natural Science Foundation of China[61335001] ; Natural Science Foundation of China[61222508] ; Shanghai Rising-Star Program[16QA1401400] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000393355900007 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275653]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Li, Jia; Wu, Changfeng; He, Xiao-Peng |
| 作者单位 | 1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Adv Mat Lab, 130 Meilong Rd, Shanghai 200237, Peoples R China; 2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China; 3.Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China; 5.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England |
| 推荐引用方式 GB/T 7714 | Wang, Chang-Zheng,Chen, Jia-Li,Tang, Ying,et al. Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(4):3272-3276. |
| APA | Wang, Chang-Zheng.,Chen, Jia-Li.,Tang, Ying.,Zang, Yi.,Chen, Guo-Rong.,...&He, Xiao-Peng.(2017).Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents.ACS APPLIED MATERIALS & INTERFACES,9(4),3272-3276. |
| MLA | Wang, Chang-Zheng,et al."Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents".ACS APPLIED MATERIALS & INTERFACES 9.4(2017):3272-3276. |
入库方式： OAI收割
来源：上海药物研究所
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