Identification of a diverse synthetic abietane diterpenoid library for anticancer activity
文献类型：期刊论文
| 作者 | Xu, Hongtao1,2; Liu, Lili1; Fan, Xiaoting1,4; Zhang, Guanjun3; Li, Yuanchao2; Jiang, Biao1 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2017-02-01 |
| 卷号 | 27期号:3页码:505-510 |
| 关键词 | Abietic acid Triptophenolide Diverse Natural-product-like Anticancer |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2016.12.032 |
| 文献子类 | Article |
| 英文摘要 | A diverse natural-product-like synthetic abietane diterpenoid library contains about 56 compounds were obtained, and evaluated for their potential in vitro cytotoxic or antitumor activity against A549, PC-3 and SKOV-3 tumor cell lines by SRB assay. Treatment of A549 cells with the most potent compound ketone 19 showed induction of apoptosis, as revealed by JC-1 mitochondrial membrane potential staining, TUNNEL assay, western blotting analysis and flow cytometry assay. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BIOLOGICAL EVALUATION ; ANTIBACTERIAL DISCOVERY ; TRIPTOLIDE ANALOGS ; ACID-DERIVATIVES ; RING-DISTORTION ; DESIGN ; CELLS ; TRIPTONIDE ; COMPLEX ; DRUGS |
| 资助项目 | National Natural Science Foundation of NFSC, China[21502114] ; China Postdoctoral Science Foundation[2015M581677] ; Open Foundation of the State Key Laboratory of Drug Research, China[SIMM1601KF-05] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000392900600025 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275656]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Jiang, Biao |
| 作者单位 | 1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Tianjin Univ Sci & Technol, Coll Chem Engn & Mat Sci, Tianjin 300457, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Hongtao,Liu, Lili,Fan, Xiaoting,et al. Identification of a diverse synthetic abietane diterpenoid library for anticancer activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(3):505-510. |
| APA | Xu, Hongtao,Liu, Lili,Fan, Xiaoting,Zhang, Guanjun,Li, Yuanchao,&Jiang, Biao.(2017).Identification of a diverse synthetic abietane diterpenoid library for anticancer activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(3),505-510. |
| MLA | Xu, Hongtao,et al."Identification of a diverse synthetic abietane diterpenoid library for anticancer activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.3(2017):505-510. |
入库方式： OAI收割
来源：上海药物研究所
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