Pd(II)-catalyzed cascade Heck/intramolecular C(sp(2))-H amidation reaction: An efficient route to 4-aryl-2-quinolinones
文献类型：期刊论文
| 作者 | Xiao, Chengqian; Wang, Ziyi; Lei, Min ; Hu, Lihong
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2017-01-12 |
| 卷号 | 73期号:2页码:204-211 |
| 关键词 | 4-Aryl-2-quinolinone C(sp(2))-H activation Intramolecular amidation Directing group Cascade reaction |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2016.11.075 |
| 文献子类 | Article |
| 英文摘要 | A Pd(II)-catalyzed cascade Heck/intramolecular C(sp(2))-H amidation reaction is described for the synthesis of 4-aryl-2-quinolinone derivatives. Substituted cinnamamide containing 2-(pyridin-2-yl)ethanamine unit reacts with aryl iodide to form intermediate by Heck reaction. Then, the intermediate takes place intramolecular amidation via C(sp(2))-H activated process promoted by orientation group. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CANCER ; 2-QUINOLINONES ; DERIVATIVES ; ACTIVATION ; ANALOGS |
| 资助项目 | National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81473110] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000392044200011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275678]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lei, Min; Hu, Lihong |
| 作者单位 | Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Chengqian,Wang, Ziyi,Lei, Min,et al. Pd(II)-catalyzed cascade Heck/intramolecular C(sp(2))-H amidation reaction: An efficient route to 4-aryl-2-quinolinones[J]. TETRAHEDRON,2017,73(2):204-211. |
| APA | Xiao, Chengqian,Wang, Ziyi,Lei, Min,&Hu, Lihong.(2017).Pd(II)-catalyzed cascade Heck/intramolecular C(sp(2))-H amidation reaction: An efficient route to 4-aryl-2-quinolinones.TETRAHEDRON,73(2),204-211. |
| MLA | Xiao, Chengqian,et al."Pd(II)-catalyzed cascade Heck/intramolecular C(sp(2))-H amidation reaction: An efficient route to 4-aryl-2-quinolinones".TETRAHEDRON 73.2(2017):204-211. |
入库方式： OAI收割
来源：上海药物研究所
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