Concise synthesis and PTP1B inhibitory activity of (R)- and (S)-dihydroresorcylide
文献类型：期刊论文
| 作者 | Jiang, Cheng-Shi1,2; Zhang, Li1; Gong, Jing-Xu1; Li, Jing-Ya1 ; Yao, Li-Gong1; Li, Jia1; Guo, Yue-Wei1
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 19期号:12页码:1204-1213 |
| 关键词 | Synthesis dihydroresorcylide PTP1B inhibitory activity molecular docking |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2017.1317752 |
| 文献子类 | Article |
| 英文摘要 | The present study was designed to develop a concise synthetic route for macrolide, with the purpose of confirming the absolute configuration of natural dihydroresorcylide (1) and making it more easily accessible for biological evaluation. The absolute configuration of C-3 in natural 1 was revised to be R by comparison of the rotation sign of synthetic (R)- and (S)-1. The synthetic (R)-1 was found to be a novel highly specific PTP1B inhibitor with an IC50 value of 17.06M. [GRAPHICS] . |
| WOS关键词 | PROTEIN-TYROSINE-PHOSPHATASE ; RESORCYLIC ACID LACTONES ; BIOLOGICAL EVALUATION ; 1B ; DERIVATIVES ; BIOSYNTHESIS ; MACROLIDES ; DISCOVERY ; STRATEGY ; DESIGN |
| 资助项目 | Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[41476063] ; Natural Science Foundation of China[21672230] ; SCTSM Projects[14431901100] ; SCTSM Projects[15431901000] ; SKLDR/SIMM Project[SIMM1501ZZ-03] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000416032900009 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275693]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Cheng-Shi,Zhang, Li,Gong, Jing-Xu,et al. Concise synthesis and PTP1B inhibitory activity of (R)- and (S)-dihydroresorcylide[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2017,19(12):1204-1213. |
| APA | Jiang, Cheng-Shi.,Zhang, Li.,Gong, Jing-Xu.,Li, Jing-Ya.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2017).Concise synthesis and PTP1B inhibitory activity of (R)- and (S)-dihydroresorcylide.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,19(12),1204-1213. |
| MLA | Jiang, Cheng-Shi,et al."Concise synthesis and PTP1B inhibitory activity of (R)- and (S)-dihydroresorcylide".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 19.12(2017):1204-1213. |
入库方式： OAI收割
来源：上海药物研究所
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