Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies
文献类型：期刊论文
| 作者 | Guan, Haixing1; Du, Yongli1; Han, Weiwei1; Shen, Jingkang2; Li, Qunyi3 |
| 刊名 | ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2017 |
| 卷号 | 17期号:5页码:646-657 |
| 关键词 | Anti-cancer agents cell cycle clinical trials cyclin-dependent kinases 4 selective inhibitors structure activity relationship (SAR) |
| ISSN号 | 1871-5206 |
| DOI | 10.2174/1871520617666170103095527 |
| 文献子类 | Review |
| 英文摘要 | Cyclin-Dependent Kinases 4 (CDK4) belongs to a family of serine-threonine protein kinase and plays key regulatory role in G1-phase of cell cycle progression. Compelling evidences have shown that targeting CDK4 pathway is an attractive proposition for tumor therapy. Recent progresses of selective small molecule CDK4 inhibitors in cancer therapy have endorsed the field to be interested and attractive. In this review, we will discuss the recent developments of CDK4 inhibitors on several aspects such as the structure of CDK4, the working mechanism of CDK4 inhibitors, the structure activity relationships(SARs) of the selective CDK4 inhibitors and the latest developments of the selective CDK4 inhibitors in clinical trials. |
| WOS关键词 | SQUAMOUS-CELL CARCINOMAS ; CRYSTAL-STRUCTURE ; CDK INHIBITORS ; BREAST-CANCER ; CHEMICAL-CONSTITUENTS ; STRUCTURAL BASIS ; LIBRARY DESIGN ; DISCOVERY ; COMPLEX ; POTENT |
| 资助项目 | National Natural Science Foundation of China[81202389] ; National Natural Science Foundation of China[81302853] |
| WOS研究方向 | Oncology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000403217100002 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275712]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Du, Yongli; Shen, Jingkang |
| 作者单位 | 1.Qilu Univ Technol, Sch Chem & Pharmaceut Engn, 3501 Daxue Rd, Jinan 250353, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 3.Fudan Univ, Huashan Hosp, Clin Pharm Lab, 12 Wu Lu Mu Qi M Rd, Shanghai 200040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Haixing,Du, Yongli,Han, Weiwei,et al. Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,2017,17(5):646-657. |
| APA | Guan, Haixing,Du, Yongli,Han, Weiwei,Shen, Jingkang,&Li, Qunyi.(2017).Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,17(5),646-657. |
| MLA | Guan, Haixing,et al."Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies".ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 17.5(2017):646-657. |
入库方式： OAI收割
来源：上海药物研究所
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