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Two pairs of rare naturally occurring 4-hydroxy-4-methyl-2,5-heptanedione derivatives from the red alga Chondria crassicaulis

文献类型：期刊论文

作者Tong, Lin1; Zhang, Yi1; Liu, Ai-Hong2; Yao, Li-Gong3; Guo, Yue-Wei3; Mao, Shui-Chun1; Wang, Bin1
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
出版日期2017
卷号19期号:6页码:572-580
关键词Red algae Chondria crassicaulis 4-hydroxy-4-methyl-2,5-heptanedione antifungal activity receptor tyrosine kinase inhibitory activity
ISSN号1028-6020
DOI10.1080/10286020.2017.1317753
文献子类Article
英文摘要Two pairs of rare naturally occurring racemic lipids, (+/-)-4,7-dihydroxy-4-methyl-2,5-heptanedione (1), and (+/-)-7-butoxy-4-hydroxy-4-methyl-2,5-heptanedione (2) were isolated from the red alga Chondria crassicaulis Harv. The structures of the racemic mixtures of 1 and 2 were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, and HMBC) as well as mass spectrometry and optical rotation experiments, and by comparison with data for related known analogs. This is the first report of naturally occurring 4-hydroxy-4-methyl-2,5-heptanedione derivatives. Antifungal, PTP1B inhibitory, and receptor tyrosine kinase inhibitory activities of these two compounds were investigated. The results showed that compounds 1 and 2 exhibited good selective inhibition against RET tyrosine kinase activity with IC50 values of 9.56 and 8.93 mu M, respectively. Compound 1 also displayed moderate antifungal activity against Cryptococcus neoformans (32609), showing a MIC80 value of 32 mu g/ml.
WOS关键词CAULERPA-RACEMOSA ; TYROSINE KINASE ; ARMATA ; CONSTITUENTS ; INHIBITOR ; EXTRACTS ; ANTIGEN
资助项目National Natural Science Foundation of China[81001397] ; National Natural Science Foundation of China[21162016] ; National Natural Science Foundation of China[21362024] ; Young Scientists Training Program of Jiangxi Province[20133BCB23004] ; Natural Science Foundation of Jiangxi Province[20151BAB205082] ; Natural Science Foundation of Jiangxi Province[20161BAB205211] ; State Key Laboratory of Drug Research-SIMM[SIMM1601KF-10]
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000401984100006
出版者TAYLOR & FRANCIS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/275716]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Mao, Shui-Chun; Wang, Bin
作者单位1.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China;
2.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Jiangxi, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Tong, Lin,Zhang, Yi,Liu, Ai-Hong,et al. Two pairs of rare naturally occurring 4-hydroxy-4-methyl-2,5-heptanedione derivatives from the red alga Chondria crassicaulis[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2017,19(6):572-580.
APA Tong, Lin.,Zhang, Yi.,Liu, Ai-Hong.,Yao, Li-Gong.,Guo, Yue-Wei.,...&Wang, Bin.(2017).Two pairs of rare naturally occurring 4-hydroxy-4-methyl-2,5-heptanedione derivatives from the red alga Chondria crassicaulis.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,19(6),572-580.
MLA Tong, Lin,et al."Two pairs of rare naturally occurring 4-hydroxy-4-methyl-2,5-heptanedione derivatives from the red alga Chondria crassicaulis".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 19.6(2017):572-580.

入库方式： OAI收割

来源：上海药物研究所

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