Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria
文献类型：期刊论文
| 作者 | Yang, Min1,2; Liang, Lin-Fu1,3; Wang, Ting1; Wang, He-Yao1 ; Liu, Hai-Li1; Guo, Yue-Wei1
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2017 |
| 卷号 | 19期号:7页码:732-737 |
| 关键词 | Brominated polyacetylene sponge Xestospongia testudinaria pancreatic lipase inhibitory activity |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2016.1274308 |
| 文献子类 | Article |
| 英文摘要 | A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2-4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50 value of 0.61M, being comparable to that of the positive control orlistat (IC50=0.78M). |
| WOS关键词 | SARCOPHYTON-TROCHELIOPHORUM MARENZELLER ; POLYUNSATURATED LIPIDS ; PTP1B INHIBITORS ; ACETYLENIC ACIDS ; DITERPENOIDS ; OBESITY |
| 资助项目 | Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[41476063] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120152039] ; SKLDR/SIMM Project[SIMM1501ZZ-03] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000401985700014 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275718]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Wang, He-Yao; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Min,Liang, Lin-Fu,Wang, Ting,et al. Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2017,19(7):732-737. |
| APA | Yang, Min,Liang, Lin-Fu,Wang, Ting,Wang, He-Yao,Liu, Hai-Li,&Guo, Yue-Wei.(2017).Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,19(7),732-737. |
| MLA | Yang, Min,et al."Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 19.7(2017):732-737. |
入库方式： OAI收割
来源：上海药物研究所
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