Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes
文献类型：期刊论文
| 作者 | Su, Jinghan1,2,3; Sun, Huiping1,2,4; Meng, Qingshuo1,2,3; Zhang, Pengcheng1,2 ; Yin, Qi1,2; Li, Yaping1,2,3
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| 刊名 | THERANOSTICS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:3页码:523-537 |
| 关键词 | Mesoporous silica nanoparticles RBC-mimetic Drug release Fluorescence imaging Metastasis |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.17259 |
| 文献子类 | Article |
| 英文摘要 | Mesoporous silica nanoparticles (MSNs), with their large surface area and tunable pore sizes, have been widely applied for anticancer therapeutic cargos delivery with a high loading capacity. However, easy aggregation in saline buffers and limited blood circulation lifetime hinder their delivery efficiency and the anticancer efficacy. Here, new multifunctional MSNs-supported red-blood-cell (RBC)-mimetic theranostic nanoparticles with long blood circulation, deep-red light-activated tumor imaging and drug release were reported. High loading capacities were achieved by camouflaging MSNs with RBC membrane to co-load an anticancer drug doxorubicin (Dox) (39.1 wt%) and a near-infrared photosensitizer chlorin e6 (Ce6) (21.1 wt%). The RBC membrane-coating protected drugs from leakage, and greatly improved the colloidal stability of MSNs, with negligible particle size change over two weeks. Upon an external laser stimuli, the RBC membrane could be destroyed, resulting in 10 times enhancement of Dox release. In a 4T1 breast cancer mouse model, the RBC-mimetic MSNs could realize in vivo tumor imaging with elongated tumor accumulation lifetime for over 24 h, and laser-activated tumor-specific Dox accumulation. The RBC-mimetic MSNs could integrate the Ce6-based photodynamic therapy and Dox-based chemotherapy, completely suppress the primary tumor growth and inhibit metastasis of breast cancer, which could provide a new strategy for optimization of MSNs and efficient anticancer drug delivery. |
| WOS关键词 | CELL-MEMBRANE ; PHOTODYNAMIC THERAPY ; BREAST-CANCER ; POLYMERIC NANOPARTICLES ; GENE DELIVERY ; GOLD NANORODS ; RESISTANCE ; SHELL ; CHEMOTHERAPY ; PENETRATION |
| 资助项目 | National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81630052] ; Key Research Projects of the Frontier Science of the Chinese Academy of Sciences[QYZDJ-SSW-SMC020] ; National Basic Research Program of China[2014CB931902] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000396557300002 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275726]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Jinghan,Sun, Huiping,Meng, Qingshuo,et al. Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes[J]. THERANOSTICS,2017,7(3):523-537. |
| APA | Su, Jinghan,Sun, Huiping,Meng, Qingshuo,Zhang, Pengcheng,Yin, Qi,&Li, Yaping.(2017).Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes.THERANOSTICS,7(3),523-537. |
| MLA | Su, Jinghan,et al."Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes".THERANOSTICS 7.3(2017):523-537. |
入库方式： OAI收割
来源：上海药物研究所
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