A one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate
文献类型：期刊论文
| 作者 | Li, You1,2,3; Liu, Tongchao2,3,4; Li, Chungang5; Xiong, Bing2,3 ; Zhao, Dongmei4; Cheng, Maosheng4; Chen, Guohua1; Shen, Jingkang2,3; Chen, Yue-Lei2,3
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| 刊名 | SYNTHETIC COMMUNICATIONS
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| 出版日期 | 2017 |
| 卷号 | 47期号:4页码:357-363 |
| 关键词 | Beta-amino ketone omarigliptin one pot synthesis reductive amination stabilization effect |
| ISSN号 | 0039-7911 |
| DOI | 10.1080/00397911.2016.1265129 |
| 文献子类 | Article |
| 英文摘要 | We have discovered a unique stabilization condition for beta-amino ketone 7. With compound 7 as an unprecedented intermediate, omarigliptin 1 could be prepared in a highly efficient one-pot procedure with good yield. Also with this intermediate 7, some analogues of omarigliptin 1 were readily prepared for the first time. |
| WOS关键词 | ACTING DPP-4 INHIBITOR |
| 资助项目 | National Natural Science Foundation of China[81673309] ; National Natural Science Foundation of China[81273368] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program," China[2014ZX09507-002] ; "Personalized Medicines-Molecular Signature-based Drug Discovery and Development," Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020310] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000395034800015 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275735]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Chen, Yue-Lei |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing, Peoples R China; 4.Shenyang Pharmaceut Univ, Shenyang, Peoples R China; 5.Shanghai Shynedec Pharmaceut Co Ltd, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, You,Liu, Tongchao,Li, Chungang,et al. A one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate[J]. SYNTHETIC COMMUNICATIONS,2017,47(4):357-363. |
| APA | Li, You.,Liu, Tongchao.,Li, Chungang.,Xiong, Bing.,Zhao, Dongmei.,...&Chen, Yue-Lei.(2017).A one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate.SYNTHETIC COMMUNICATIONS,47(4),357-363. |
| MLA | Li, You,et al."A one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate".SYNTHETIC COMMUNICATIONS 47.4(2017):357-363. |
入库方式： OAI收割
来源：上海药物研究所
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