Smart nanoparticles improve therapy for drug resistant tumors by overcoming pathophysiological barriers
文献类型：期刊论文
| 作者 | Liu, Jian-ping1,2,3; Wang, Ting-ting2,3; Wang, Dang-ge2,3; Dong, An-jie1; Li, Ya-ping2,3 ; Yu, Hai-jun2,3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2017-01 |
| 卷号 | 38期号:1页码:1-8 |
| 关键词 | solid tumors chemotherapy drug resistance pathophysiological barriers tumor microenvironment nanomedicine smart nanoparticles |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2016.84 |
| 文献子类 | Review |
| 英文摘要 | The therapeutic:outcome of chemotherapy is severely limited by intrinsic or acquired drug resistance, the most common causes of chemotherapy failure. In the past few decades, advancements in nanotechnology have provided alternative strategies for combating tumor drug resistance. Drug-loaded nanoparticles (NPs) have several advantages over the free drug forms, including reduced cytotoxicity, prolonged circulation in the blood and increased accumulation in tumors. Currently, however, nanoparticulate drugs have only marginally improved the overall survival rate in clinical trials because of the various pathophysiological barriers that exist in the tumor microenvironment, such as intratumoral distribution, penetration and intracellular trafficking, etc. Smart NPs with stimulus adaptable physico-chemical properties have been extensively developed to improve the therapeutic efficacy of nanomedicine. In this review, we summarize the recent advances of employing smart NPs to treat the drug-resistant tumors by overcoming the pathophysiological barriers in the tumor microenvironment. |
| WOS关键词 | CANCER-THERAPY ; SOLID TUMORS ; IN-VIVO ; PHOTODYNAMIC THERAPY ; BIOLOGICAL BARRIERS ; EFFICIENT ABLATION ; POLYMERIC MICELLES ; CONTROLLED-RELEASE ; DELIVERY-SYSTEM ; SIRNA DELIVERY |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[81373359] ; Youth Innovation Promotion Association of CAS[2014248] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000393540900001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275738]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Dong, An-jie; Yu, Hai-jun |
| 作者单位 | 1.Tianjin Univ, Sch Chem Engn & Technol, Dept Polymer Sci & Technol, Key Lab Syst Bioengn,Minist Educ, Tianjin 300072, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jian-ping,Wang, Ting-ting,Wang, Dang-ge,et al. Smart nanoparticles improve therapy for drug resistant tumors by overcoming pathophysiological barriers[J]. ACTA PHARMACOLOGICA SINICA,2017,38(1):1-8. |
| APA | Liu, Jian-ping,Wang, Ting-ting,Wang, Dang-ge,Dong, An-jie,Li, Ya-ping,&Yu, Hai-jun.(2017).Smart nanoparticles improve therapy for drug resistant tumors by overcoming pathophysiological barriers.ACTA PHARMACOLOGICA SINICA,38(1),1-8. |
| MLA | Liu, Jian-ping,et al."Smart nanoparticles improve therapy for drug resistant tumors by overcoming pathophysiological barriers".ACTA PHARMACOLOGICA SINICA 38.1(2017):1-8. |
入库方式： OAI收割
来源：上海药物研究所
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