New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation
文献类型：期刊论文
| 作者 | Pan, Hui-qin1,2; Yang, Wen-zhi1; Zhao, Dan3; Luo, Cheng3 ; Yao, Chang-liang1,2; Shi, Xiao-jian1; Zhang, Yi-bei1; Li, Shi-you4; Bi, Ying4; Wang, Zhen4
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2017-01 |
| 卷号 | 116页码:85-92 |
| 关键词 | Uncaria hirsuta Monoterpenoid oxindole alkaloid MDA-MB-231 Collision-induced dissociation |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2016.11.013 |
| 文献子类 | Article |
| 英文摘要 | Four new alkaloids, comprising three 3-oxo-3,7-seco-oxindole alkaloids (hirsutanine D-F, 1-3) and one oxindole alkaloid N-oxide (uncarine B N-oxide, 4), together with four known heteroyohimbine-type oxindole alkaloids, were isolated from the stems of Uncaria hirsuta Havil. Structures of 1-4 were elucidated by extensive NMR and HR-ESIMS data analyses. Compound 3 is the first 3-oxo-3,7-seco-oxindole alkaloid with ring B opened and degraded isolated from the Uncaria genus. Compounds 1-3 exhibited slight inhibition effect on the proliferation of the breast cancer cell MDA-MB-231. The positive mode collision-induced dissociation of the 3-oxo-3,7-secooxindole alkaloids (1-3) was featured by the beta-cleavage and alpha-cleavage of the amido bond, while the N-oxide (4) showed characteristic neutral eliminations of (OH)-O-center dot and H2O. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS关键词 | INDOLE ALKALOIDS ; ABSOLUTE-CONFIGURATION ; CELL-LINES ; N-OXIDES ; A-D ; RHYNCHOPHYLLA ; TOMENTOSA ; ISORHYNCHOPHYLLINE ; PHYTOCHEMISTRY ; RHYNCHOCILINE |
| 资助项目 | National Natural Science Foundation of China[81673591] ; National Science and Technology Major Project for Major Drug Development[2014ZX09304-307-001-007] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000392779200013 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275743]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wu, Wan-ying; Guo, De-an |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Beijing Inst Genom, 1 Beichen West Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Hui-qin,Yang, Wen-zhi,Zhao, Dan,et al. New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation[J]. FITOTERAPIA,2017,116:85-92. |
| APA | Pan, Hui-qin.,Yang, Wen-zhi.,Zhao, Dan.,Luo, Cheng.,Yao, Chang-liang.,...&Guo, De-an.(2017).New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation.FITOTERAPIA,116,85-92. |
| MLA | Pan, Hui-qin,et al."New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation".FITOTERAPIA 116(2017):85-92. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。