New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation
文献类型:期刊论文
作者 | Pan, Hui-qin1,2; Yang, Wen-zhi1; Zhao, Dan3; Luo, Cheng3![]() ![]() |
刊名 | FITOTERAPIA
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出版日期 | 2017-01 |
卷号 | 116页码:85-92 |
关键词 | Uncaria hirsuta Monoterpenoid oxindole alkaloid MDA-MB-231 Collision-induced dissociation |
ISSN号 | 0367-326X |
DOI | 10.1016/j.fitote.2016.11.013 |
文献子类 | Article |
英文摘要 | Four new alkaloids, comprising three 3-oxo-3,7-seco-oxindole alkaloids (hirsutanine D-F, 1-3) and one oxindole alkaloid N-oxide (uncarine B N-oxide, 4), together with four known heteroyohimbine-type oxindole alkaloids, were isolated from the stems of Uncaria hirsuta Havil. Structures of 1-4 were elucidated by extensive NMR and HR-ESIMS data analyses. Compound 3 is the first 3-oxo-3,7-seco-oxindole alkaloid with ring B opened and degraded isolated from the Uncaria genus. Compounds 1-3 exhibited slight inhibition effect on the proliferation of the breast cancer cell MDA-MB-231. The positive mode collision-induced dissociation of the 3-oxo-3,7-secooxindole alkaloids (1-3) was featured by the beta-cleavage and alpha-cleavage of the amido bond, while the N-oxide (4) showed characteristic neutral eliminations of (OH)-O-center dot and H2O. (C) 2016 Elsevier B.V. All rights reserved. |
WOS关键词 | INDOLE ALKALOIDS ; ABSOLUTE-CONFIGURATION ; CELL-LINES ; N-OXIDES ; A-D ; RHYNCHOPHYLLA ; TOMENTOSA ; ISORHYNCHOPHYLLINE ; PHYTOCHEMISTRY ; RHYNCHOCILINE |
资助项目 | National Natural Science Foundation of China[81673591] ; National Science and Technology Major Project for Major Drug Development[2014ZX09304-307-001-007] |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000392779200013 |
出版者 | ELSEVIER SCIENCE BV |
源URL | [http://119.78.100.183/handle/2S10ELR8/275743] ![]() |
专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
通讯作者 | Wu, Wan-ying; Guo, De-an |
作者单位 | 1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Beijing Inst Genom, 1 Beichen West Rd, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Pan, Hui-qin,Yang, Wen-zhi,Zhao, Dan,et al. New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation[J]. FITOTERAPIA,2017,116:85-92. |
APA | Pan, Hui-qin.,Yang, Wen-zhi.,Zhao, Dan.,Luo, Cheng.,Yao, Chang-liang.,...&Guo, De-an.(2017).New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation.FITOTERAPIA,116,85-92. |
MLA | Pan, Hui-qin,et al."New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation".FITOTERAPIA 116(2017):85-92. |
入库方式: OAI收割
来源:上海药物研究所
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