中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation

文献类型:期刊论文

作者Pan, Hui-qin1,2; Yang, Wen-zhi1; Zhao, Dan3; Luo, Cheng3; Yao, Chang-liang1,2; Shi, Xiao-jian1; Zhang, Yi-bei1; Li, Shi-you4; Bi, Ying4; Wang, Zhen4
刊名FITOTERAPIA
出版日期2017-01
卷号116页码:85-92
关键词Uncaria hirsuta Monoterpenoid oxindole alkaloid MDA-MB-231 Collision-induced dissociation
ISSN号0367-326X
DOI10.1016/j.fitote.2016.11.013
文献子类Article
英文摘要Four new alkaloids, comprising three 3-oxo-3,7-seco-oxindole alkaloids (hirsutanine D-F, 1-3) and one oxindole alkaloid N-oxide (uncarine B N-oxide, 4), together with four known heteroyohimbine-type oxindole alkaloids, were isolated from the stems of Uncaria hirsuta Havil. Structures of 1-4 were elucidated by extensive NMR and HR-ESIMS data analyses. Compound 3 is the first 3-oxo-3,7-seco-oxindole alkaloid with ring B opened and degraded isolated from the Uncaria genus. Compounds 1-3 exhibited slight inhibition effect on the proliferation of the breast cancer cell MDA-MB-231. The positive mode collision-induced dissociation of the 3-oxo-3,7-secooxindole alkaloids (1-3) was featured by the beta-cleavage and alpha-cleavage of the amido bond, while the N-oxide (4) showed characteristic neutral eliminations of (OH)-O-center dot and H2O. (C) 2016 Elsevier B.V. All rights reserved.
WOS关键词INDOLE ALKALOIDS ; ABSOLUTE-CONFIGURATION ; CELL-LINES ; N-OXIDES ; A-D ; RHYNCHOPHYLLA ; TOMENTOSA ; ISORHYNCHOPHYLLINE ; PHYTOCHEMISTRY ; RHYNCHOCILINE
资助项目National Natural Science Foundation of China[81673591] ; National Science and Technology Major Project for Major Drug Development[2014ZX09304-307-001-007]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000392779200013
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/275743]  
专题上海中药现代化研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Wu, Wan-ying; Guo, De-an
作者单位1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China;
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
4.Chinese Acad Sci, Beijing Inst Genom, 1 Beichen West Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Pan, Hui-qin,Yang, Wen-zhi,Zhao, Dan,et al. New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation[J]. FITOTERAPIA,2017,116:85-92.
APA Pan, Hui-qin.,Yang, Wen-zhi.,Zhao, Dan.,Luo, Cheng.,Yao, Chang-liang.,...&Guo, De-an.(2017).New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation.FITOTERAPIA,116,85-92.
MLA Pan, Hui-qin,et al."New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation".FITOTERAPIA 116(2017):85-92.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。