Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer
文献类型：期刊论文
| 作者 | Tang, Shan; Meng, Qingshuo; Sun, Huiping; Su, Jinghan; Yin, Qi ; Zhang, Zhiwen; Yu, Haijun; Chen, Lingli; Gu, Wangwen; Li, Yaping
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| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2017-01 |
| 卷号 | 114页码:44-53 |
| 关键词 | Breast cancer Charge-switch Metastasis Micelle pH-sensitive |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2016.06.005 |
| 文献子类 | Article |
| 英文摘要 | For successful chemotherapy against metastatic breast cancer, the great efforts are still required for designing drug delivery systems that can be selectively internalized by tumor cells and release the cargo in a controlled manner. In this work, the chemotherapeutic agent paclitaxel (PTX) was loaded with the dual-pH sensitive micelle (DPM), which consisted of a pH-sensitive core, an acid-cleavable anionic shell, and a polyethylene glycol (PEG) corona. In the slightly acidic environment of tumor tissues, the anionic shell was taken off, inducing the conversion of the surface charge of DPM from negative to positive, which resulted in more efficient cellular uptake, stronger cytotoxicity and higher intra-tumor accumulation of PTX in the murine breast cancer 4T1 tumor-bearing mice models compared to the micelles with irremovable anionic or non-ionic shell. Meanwhile, the pH-sensitive core endowed DPM with rapid drug release in endo/lysosomes. The inhibitory rates of DPM against tumor growth and lung metastasis achieved 77.7% and 88.3%, respectively, without significant toxicity. Therefore, DPM is a promising nanocarrier for effective therapy of metastatic breast cancer due to satisfying the requirements of both selective uptake by tumor cells and sufficient and fast intracellular drug release. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | AMINO ESTER NANOPARTICLES ; HEPATOCELLULAR-CARCINOMA ; POLYMERIC NANOPARTICLES ; TARGETED DELIVERY ; CO-DELIVERY ; CELLS ; SURFACE ; DOXORUBICIN ; TUMOR ; SIRNA |
| 资助项目 | National Basic Research Program of China[2014CB931900] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81230029] ; National Natural Science Foundation of China[81302712] ; Youth Innovation Promotion Association of CAS[2015226] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000389730000005 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275754]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yin, Qi; Li, Yaping |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Shan,Meng, Qingshuo,Sun, Huiping,et al. Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer[J]. BIOMATERIALS,2017,114:44-53. |
| APA | Tang, Shan.,Meng, Qingshuo.,Sun, Huiping.,Su, Jinghan.,Yin, Qi.,...&Li, Yaping.(2017).Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer.BIOMATERIALS,114,44-53. |
| MLA | Tang, Shan,et al."Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer".BIOMATERIALS 114(2017):44-53. |
入库方式： OAI收割
来源：上海药物研究所
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