Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata
文献类型：期刊论文
| 作者 | Lei, Chun1; Zhang, Lai-Bin1; Yang, Jing2; Gao, Li-Xin3; Li, Jing-Ya3 ; Li, Jia3; Hou, Ai-Jun1
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2016-12-07 |
| 卷号 | 57期号:49页码:5475-5478 |
| 关键词 | Macaranga denticulate Euphorbiaceae Dimeric chalcone Macdentichalcone Protein tyrosine phosphatase 1B |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2016.10.090 |
| 文献子类 | Article |
| 英文摘要 | Macdentichalcone (1), an unprecedented polycyclic dimeric chalcone featuring a unique quinonoid moiety, was isolated from Macaranga denticulate, together with 1-(5,7-dihydroxy-2,2,6-trimethy1-2H1-benzopyran-8-y1)-3-pheny1-2-propen-1-one (2), a known monomeric chalcone proposed as a biosynthetic precursor of 1. The structure of 1 was elucidated by extensive spectroscopic analysis including NMR and MS data, as well as calculation of C-13 NMR chemical shifts. Both compounds 1 and 2 showed inhibitory activity against PTP1B in vitro. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MALLOTUS-PHILIPPINENSIS ; BIOACTIVITIES ; CONSTITUENTS ; DERIVATIVES ; FLAVONOIDS ; INHIBITOR ; ADDUCTS ; PLANTS |
| 资助项目 | National Natural Science Foundation of China[81222045] ; National Natural Science Foundation of China[21372049] ; Shu Guang Project from Shanghai Municipal Education Commission[12SG02] ; Shanghai Education Development Foundation[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000389096600015 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275769]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Hou, Ai-Jun |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Chun,Zhang, Lai-Bin,Yang, Jing,et al. Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata[J]. TETRAHEDRON LETTERS,2016,57(49):5475-5478. |
| APA | Lei, Chun.,Zhang, Lai-Bin.,Yang, Jing.,Gao, Li-Xin.,Li, Jing-Ya.,...&Hou, Ai-Jun.(2016).Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata.TETRAHEDRON LETTERS,57(49),5475-5478. |
| MLA | Lei, Chun,et al."Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata".TETRAHEDRON LETTERS 57.49(2016):5475-5478. |
入库方式： OAI收割
来源：上海药物研究所
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