中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata

文献类型:期刊论文

作者Lei, Chun1; Zhang, Lai-Bin1; Yang, Jing2; Gao, Li-Xin3; Li, Jing-Ya3; Li, Jia3; Hou, Ai-Jun1
刊名TETRAHEDRON LETTERS
出版日期2016-12-07
卷号57期号:49页码:5475-5478
关键词Macaranga denticulate Euphorbiaceae Dimeric chalcone Macdentichalcone Protein tyrosine phosphatase 1B
ISSN号0040-4039
DOI10.1016/j.tetlet.2016.10.090
文献子类Article
英文摘要Macdentichalcone (1), an unprecedented polycyclic dimeric chalcone featuring a unique quinonoid moiety, was isolated from Macaranga denticulate, together with 1-(5,7-dihydroxy-2,2,6-trimethy1-2H1-benzopyran-8-y1)-3-pheny1-2-propen-1-one (2), a known monomeric chalcone proposed as a biosynthetic precursor of 1. The structure of 1 was elucidated by extensive spectroscopic analysis including NMR and MS data, as well as calculation of C-13 NMR chemical shifts. Both compounds 1 and 2 showed inhibitory activity against PTP1B in vitro. (C) 2016 Elsevier Ltd. All rights reserved.
WOS关键词MALLOTUS-PHILIPPINENSIS ; BIOACTIVITIES ; CONSTITUENTS ; DERIVATIVES ; FLAVONOIDS ; INHIBITOR ; ADDUCTS ; PLANTS
资助项目National Natural Science Foundation of China[81222045] ; National Natural Science Foundation of China[21372049] ; Shu Guang Project from Shanghai Municipal Education Commission[12SG02] ; Shanghai Education Development Foundation[00000000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000389096600015
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/275769]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药物安全性评价中心
通讯作者Hou, Ai-Jun
作者单位1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Lei, Chun,Zhang, Lai-Bin,Yang, Jing,et al. Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata[J]. TETRAHEDRON LETTERS,2016,57(49):5475-5478.
APA Lei, Chun.,Zhang, Lai-Bin.,Yang, Jing.,Gao, Li-Xin.,Li, Jing-Ya.,...&Hou, Ai-Jun.(2016).Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata.TETRAHEDRON LETTERS,57(49),5475-5478.
MLA Lei, Chun,et al."Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata".TETRAHEDRON LETTERS 57.49(2016):5475-5478.

入库方式: OAI收割

来源:上海药物研究所

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