The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12
文献类型：期刊论文
| 作者 | Liu, Ming-Liang1; Pan, Xue-Ying2,4; Yang, Teng3,4; Zhang, Wen -Ming1; Wang, Tian-Qi1; Wang, He-Yun1; Lin, Hai-Xia1; Yang, Cai-Guang4 ; Cui, Yong-Mei1,4
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2016-11-15 |
| 卷号 | 26期号:22页码:5492-5496 |
| 关键词 | Antistaphylococcal Multidrug-resistant Synthesis Oxime Dehydroabietic acid |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2016.10.018 |
| 文献子类 | Article |
| 英文摘要 | A series of 12-oxime and O-oxime ether derivatives of dehydroabietic acid were synthesized and investigated for the antibacterial activity against Staphylococcus aureus Newman strain and five multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). The aromatic oximate derivative 11a showed the highest activity with MIC of 0.39-0.78 mu g/mL against S. aureus Newman. Of note, compounds 10b, 11 and 14 showed the most potent antibacterial activity against five multidrug-resistant S. aureus with MIC values of 1.25-3.13 mu g/mL. These results offered useful information for further strategic optimization in search of the antibacterial candidates against infection of multidrug-resistant Gram-positive bacteria. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | AROMATIC ABIETANE DITERPENOIDS ; STAPHYLOCOCCUS-AUREUS ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; BIOLOGICAL-ACTIVITY ; TOTAROL ; BACTERIA |
| 资助项目 | National Natural Science Foundation of China[81202402] ; National Natural Science Foundation of China[21272154] ; National Natural Science Foundation of China[8161101140] ; State Key Laboratory of Drug Research[SIMM1601KF-11] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000388251400021 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275810]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Cai-Guang; Cui, Yong-Mei |
| 作者单位 | 1.Shanghai Univ, Dept Chem, Coll Sci, Innovat Drug Res Ctr, Shanghai 200444, Peoples R China; 2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China; 3.Guizhou Univ, Ctr Res & Dev Fine Chem, Guiyang 550025, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ming-Liang,Pan, Xue-Ying,Yang, Teng,et al. The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(22):5492-5496. |
| APA | Liu, Ming-Liang.,Pan, Xue-Ying.,Yang, Teng.,Zhang, Wen -Ming.,Wang, Tian-Qi.,...&Cui, Yong-Mei.(2016).The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(22),5492-5496. |
| MLA | Liu, Ming-Liang,et al."The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.22(2016):5492-5496. |
入库方式： OAI收割
来源：上海药物研究所
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