Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy
文献类型：期刊论文
| 作者 | Feng, Bing1,2,3; Zhou, Fangyuan1,2,4; Xu, Zhiai5; Wang, Tingting1,2,3; Wang, Dangge1,2,3; Liu, Jianping1,2; Fu, Yuanlei1,2; Yin, Qi1,2 ; Zhang, Zhiwen1,2; Yu, Haijun1,2
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2016-11-02 |
| 卷号 | 26期号:41页码:7431-7442 |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201602963 |
| 文献子类 | Article |
| 英文摘要 | Integration of chemotherapy with photodynamic therapy (PDT) has been emerging as a novel strategy for treatment of triple negative breast cancer (TNBC). However, the clinical translation of this approach is hindered by the unwanted dark toxicity due to the "always-on" model and low tumor specificity of currently approved photosensitizer (PS). Here, the design of a multifunctional prodrug nanoparticle (NP) is described for precise imaging and organelle-specific combination cancer therapy. The prodrug NP is composed of a newly synthesized oxaliplatin prodrug, hexadecyl-oxaliplatintrimethyleneamine (HOT), an acid-activatable PS, derivative of Chlorin e6 (AC), and functionalized with a targeting ligand iRGD for tumor homing and penetration. HOT displays much higher antitumor efficiency than oxaliplatin by simultaneously inducing mitochondria depolarizing and DNA cross-linking. AC is specifically activated in the orthotopic or metastatic TNBC tumor for fluorescence imaging and PDT, while it remains inert in blood circulation to minimize the dark toxicity. Under the guide of acid-activatable fluorescence imaging, PDT and chemotherapy can be synergistically performed for highly efficient regression of TNBC. Taken together, this versatile prodrug nanoplatform could achieve tumor-specific imaging and organelle-specific combination therapy, which can provide an alternative option for cancer theranostic. |
| WOS关键词 | NEGATIVE BREAST-CANCER ; NEAR-INFRARED LIGHT ; PHOTODYNAMIC THERAPY ; DRUG-DELIVERY ; TUMOR PENETRATION ; TARGETED THERAPY ; RESISTANT TUMOR ; SIRNA DELIVERY ; OXALIPLATIN ; EFFICACY |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[21305047] ; National Natural Science Foundation of China[31622025] ; Youth Innovation Promotion Association CAS[2014248] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000387545500007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275818]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 5.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Bing,Zhou, Fangyuan,Xu, Zhiai,et al. Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2016,26(41):7431-7442. |
| APA | Feng, Bing.,Zhou, Fangyuan.,Xu, Zhiai.,Wang, Tingting.,Wang, Dangge.,...&Li, Yaping.(2016).Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,26(41),7431-7442. |
| MLA | Feng, Bing,et al."Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS 26.41(2016):7431-7442. |
入库方式： OAI收割
来源：上海药物研究所
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