Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection
文献类型：期刊论文
| 作者 | Cheng, Chen1; Du, Feifei1; Yu, Ke1; Xu, Fang1; Wang, Fengqing1; Li, Li1; Olaleye, Olajide E.1; Yang, Junling1 ; Chen, Feng1; Zhong, Chenchun1
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| 刊名 | DRUG METABOLISM AND DISPOSITION
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| 出版日期 | 2016-11 |
| 卷号 | 44期号:11页码:1853-1858 |
| ISSN号 | 0090-9556 |
| DOI | 10.1124/dmd.116.071647 |
| 文献子类 | Article |
| 英文摘要 | ReDuNing injection, prepared from a combination of Gardenia Jasminoides fruits, Lonicera japonica flower buds, and the Artemisia annua aerial part, is extensively used for treatment of viral upper respiratory tract infections in China. Iridoids, organic acids, and flavonoids are likely important compounds of the herbal injection because of their reported pharmacological properties. This study was designed to characterize pharmacokinetics and disposition of the major circulating herbal compounds in rats that received the injection intravenously. ReDuNing injection was found to contain 19 iridoids (content levels 0.01-27.93 mM), 16 organic acids (0.04-19.06 mM), and 11 flavonoids (<0.08 mM). After dosing the injection, the iridoids geniposide, secologanic acid, secoxyloganin, genipin-1-beta-gentiobioside, geniposidic acid, sweroside, and shanzhiside and the organic acids chlorogenic acid, quinic acid, cryptochlorogenic acid, and neochlorogenic acid were found to be the major circulating compounds, with mean elimination half-lives of 0.2-0.9 hour; the other plasma compounds were at low exposure levels. These major circulating compounds exhibited small apparent volumes of distribution (0.03-0.34 l/kg). Most of the iridoids were eliminated predominantly via renal excretion of the unchanged compounds, whereas the organic acids were eliminated via methylation and sulfation and were excreted into urine as the unchanged and metabolized compounds. The methylated metabolites also underwent subsequent conjugations before hepatobiliary and renal excretion. In vitro data suggested that the metabolism of the organic acids in rats also occurred in humans. The current pharmacokinetic research could serve as a crucial step in identifying the chemical basis responsible for the therapeutic action of ReDuNing injection. |
| WOS关键词 | PLASMA ; PHYTOCHEMISTRY ; PHARMACOLOGY ; SAFETY |
| 资助项目 | National Science Fund of China for Distinguished Young Scholars[30925044] ; National Science and Technology Major Project of China "Key New Drug Creation and Manufacturing Program"[2009ZX09304-002] ; National Basic Research Program of China[2012CB518403] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS |
| WOS记录号 | WOS:000392725600017 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275821]  |
| 专题 | 上海药物代谢研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 科研与新药推进处 |
| 通讯作者 | Li, Chuan; Xiao, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; 2.Jiangsu Kanion Pharmaceut Corp, Lianyungang 222001, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Chen,Du, Feifei,Yu, Ke,et al. Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection[J]. DRUG METABOLISM AND DISPOSITION,2016,44(11):1853-1858. |
| APA | Cheng, Chen.,Du, Feifei.,Yu, Ke.,Xu, Fang.,Wang, Fengqing.,...&Xiao, Wei.(2016).Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection.DRUG METABOLISM AND DISPOSITION,44(11),1853-1858. |
| MLA | Cheng, Chen,et al."Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection".DRUG METABOLISM AND DISPOSITION 44.11(2016):1853-1858. |
入库方式： OAI收割
来源：上海药物研究所
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