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Novel Diterpenoids from the Twigs of Podocarpus nagi

文献类型：期刊论文

作者Zheng, Yuan-Dong1,2,3; Guan, Xing-Chen4; Li, Dan5; Wang, An-Qi5; Ke, Chang-Qiang1,2; Tang, Chun-Ping1,2; Lin, Li-Gen5; Ye, Yang1,2,3; Wang, Zheng-Liang4; Yao, Sheng1,2
刊名MOLECULES
出版日期2016-10
卷号21期号:10
关键词Podocarpus nagi abietane-type diterpenoid ent-pimarane-type diterpenoid cytotoxicity anti-inflammation
ISSN号1420-3049
DOI10.3390/molecules21101282
文献子类Article
英文摘要Phytochemical investigation of the twigs of Podocarpus nagi (Podocarpaceae) led to the isolation of two new abietane-type diterpenoids, named 1 beta,16-dihydroxylambertic acid (1) and 3 beta,16-dihydroxylambertic acid (2), along with two new ent-pimarane-type diterpenoids, named ent-2 beta,15,16,18-tetrahydroxypimar-8(14)-ene (3) and ent-15-oxo-2 beta,16,18-trihydroxypimar-8(14)-ene (4). Their respective structures were elucidated on the basis of spectroscopic analyses, including 1D-and 2D-NMR, IR, CD, and HR-ESI-MS. This is the first time ent-pimarane-type diterpenoids from the genus Podocarpus has been reported. All four new compounds were tested for cytotoxic activity. The MTT assay results showed that compounds 3 and 4 significantly inhibited the proliferation of human cervical cancer Hela cells, human lung cancer A549 cells, and human breast cancer MCF-7 cells at a concentration of 10 mu M. Furthermore, using the lipopolysaccharide (LPS)-stimulated RAW264.7 cells, compounds 2 and 4 were found to significantly inhibit nitrogen oxide (NO) production with IC50 values of 26.5 +/- 6.1 and 17.1 +/- 1.5 mu M, respectively.
WOS关键词CONSTITUENTS ; DILACTONES
资助项目National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Funds of China[81302657] ; National Natural Science Funds of China[81573305] ; National Natural Science Funds of China[81473112] ; Youth Innovation Promotion Association CAS[00000000] ; Ministry of Science and Technology[2010DFA30980] ; Chinese Academy of Sciences[KSZD-EW-Z-004-01] ; Shanghai Commission of Science and Technology[11DZ1970700] ; Shanghai Commission of Science and Technology[12JC1410300] ; Research Fund of University of Macau[MYRG2014-00020-ICMS-QRCM] ; Research Fund of University of Macau[MYRG2015-00153-ICMS-QRCM]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000389917900019
出版者MDPI AG
源URL[http://119.78.100.183/handle/2S10ELR8/275869]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Wang, Zheng-Liang; Yao, Sheng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Dept Chem, Shanghai 201203, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China;
4.Yangtze Univ, Sch Chem & Environm Engn, Jingzhou 434023, Peoples R China;
5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
推荐引用方式
GB/T 7714		 Zheng, Yuan-Dong,Guan, Xing-Chen,Li, Dan,et al. Novel Diterpenoids from the Twigs of Podocarpus nagi[J]. MOLECULES,2016,21(10).
APA Zheng, Yuan-Dong.,Guan, Xing-Chen.,Li, Dan.,Wang, An-Qi.,Ke, Chang-Qiang.,...&Yao, Sheng.(2016).Novel Diterpenoids from the Twigs of Podocarpus nagi.MOLECULES,21(10).
MLA Zheng, Yuan-Dong,et al."Novel Diterpenoids from the Twigs of Podocarpus nagi".MOLECULES 21.10(2016).

入库方式： OAI收割

来源：上海药物研究所

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