The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor beta 1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-beta 1 and Suppresses Tumor Metastasis
文献类型：期刊论文
| 作者 | Zhou, Ji1; You, Wenjie2; Sun, Guangqiang1; Li, Yixuan1; Chen, Bi2; Ai, Jing1 ; Jiang, Handong2
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| 刊名 | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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| 出版日期 | 2016-10-01 |
| 卷号 | 359期号:1页码:54-61 |
| ISSN号 | 0022-3565 |
| DOI | 10.1124/jpet.116.234799 |
| 文献子类 | Article |
| 英文摘要 | Metastasis accounts for the majority of cancer-related deaths. Transforming growth factor beta (TGF-beta) is believed to promote late-stage cancer progression and metastasis by inducing epithelial-mesenchymal transition (EMT). We previously reported that MS80, a novel oligosaccharide sulfate, inhibits TGF-beta 1- induced pulmonary fibrosis by binding TGF-beta 1. In our study MS80 effectively inhibited TGF-beta/Smad signaling in lung cancer cells, breast cancer cells, and model cell lines. In addition, MS80 inhibited TGF-beta 1-induced EMT, motility, and invasion in vitro. Moreover, MS80 significantly inhibited lung metastasis in orthotopic 4T1 xenografts. Notably, the MS80 treatment significantly increased the infiltration of CD8(+) T cells and decreased the infiltration of regulatory T cells in primary tumors and spleens in mice bearing 4T1 xenografts. Therefore, MS80 is a novel and promising candidate for treating metastatic malignancies by targeting TGF-beta 1-induced EMT and mediating immunosuppression. |
| WOS关键词 | I KINASE INHIBITOR ; TGF-BETA ; T-CELLS ; BREAST-CANCER ; SIGNALING PATHWAY ; LUNG METASTASIS ; RECEPTOR ; VIVO ; CARCINOMA ; PROGNOSIS |
| 资助项目 | National Natural Science Foundation of China[81274143] ; National Natural Science Foundation of China[81173610] ; National Natural Science Foundation of China[81473243] ; Youth Innovation Promotion Association[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000389067700007 |
| 出版者 | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275872]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ai, Jing; Jiang, Handong |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Med Res, Sch Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Ji,You, Wenjie,Sun, Guangqiang,et al. The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor beta 1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-beta 1 and Suppresses Tumor Metastasis[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,2016,359(1):54-61. |
| APA | Zhou, Ji.,You, Wenjie.,Sun, Guangqiang.,Li, Yixuan.,Chen, Bi.,...&Jiang, Handong.(2016).The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor beta 1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-beta 1 and Suppresses Tumor Metastasis.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,359(1),54-61. |
| MLA | Zhou, Ji,et al."The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor beta 1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-beta 1 and Suppresses Tumor Metastasis".JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 359.1(2016):54-61. |
入库方式： OAI收割
来源：上海药物研究所
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