Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis
文献类型：期刊论文
| 作者 | Xu, Jin-Biao1; Fan, Yao-Yue1; Gan, Li-She2; Zhou, Yu-Bo1 ; Li, Jia1; Yue, Jian-Min1
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2016-10 |
| 卷号 | 22期号:41页码:14648-14654 |
| 关键词 | biosynthetic pathways cephalotanins cephalotaxus norditerpenoid nf-b inhibition structural elucidation |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201603373 |
| 文献子类 | Article |
| 英文摘要 | Four polycyclic norditerpenoids, cephalotanins A-D (1-4) representing three unprecedented carbon skeletons with highly rigid ring systems, were isolated from Cephalotaxus sinensis and structurally characterized by a combination of various methods. Compounds 1 and 2 are new skeletal norditerpenoid trilactones, while 3 and 4 are two norditerpenoids featuring different new carbon skeletons. Biosynthetic pathways for 1-4 were proposed by involving diverse and very fascinating chemical events with the coexisting cephalotane troponoids as the precursors. Compound 1 exhibited good NF-B inhibition with an IC50 value of 4.12 +/- 0.61M. |
| WOS关键词 | UNUSUAL DITERPENOID TROPONE ; NF-KAPPA-B ; HARRINGTONOLIDE ; (+)-HARRINGTONOLIDE ; HAINANOLIDOL ; INHIBITOR ; REVISION ; SHIFTS |
| 资助项目 | National Natural Science Foundation of the People's Republic of China[21532007] ; National Natural Science Foundation of the People's Republic of China[U1302222] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000384698500034 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275881]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 2.Zhejiang Univ, Inst Modern Chinese Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jin-Biao,Fan, Yao-Yue,Gan, Li-She,et al. Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis[J]. CHEMISTRY-A EUROPEAN JOURNAL,2016,22(41):14648-14654. |
| APA | Xu, Jin-Biao,Fan, Yao-Yue,Gan, Li-She,Zhou, Yu-Bo,Li, Jia,&Yue, Jian-Min.(2016).Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis.CHEMISTRY-A EUROPEAN JOURNAL,22(41),14648-14654. |
| MLA | Xu, Jin-Biao,et al."Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis".CHEMISTRY-A EUROPEAN JOURNAL 22.41(2016):14648-14654. |
入库方式： OAI收割
来源：上海药物研究所
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