Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig
文献类型：期刊论文
| 作者 | Zhou, Zhen-Fang1; Kurtan, Tibor2; Mandi, Attila2; Gu, Yu-Cheng3; Yao, Li-Gong3; Xin, Guo-Rong4; Li, Xu-Wen1 ; Guo, Yue-Wei1
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-09-23 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep33908 |
| 文献子类 | Article |
| 英文摘要 | Eight new tetranortriterpenoids (1-8) were isolated from the twigs and leaves of the Chinese mangrove plant Xylocarpus granatum, together with four related known ones (9-12). The structures of new compounds were elucidated by detailed spectroscopic analysis. The absolute configuration of 9-epixylogranatin A (1) was determined by time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations of the solution conformers. Xylogranatumin A (2) represents the first example of the 9, 10-seco limonoid with an unprecedented oxygen-bridged B ring (2,7-dioxabicyclo[2.2.1]-heptane). All the isolates were evaluated for the in vitro neuroprotective activity, both compounds 11 and 12 displayed moderate effects against H2O2-induced neurotoxicity in PC12 cells at the concentration of 10 mu M, with an increase in cell viability of 12.0% and 11.6%, respectively. |
| WOS关键词 | LIMONOIDS ; SEEDS |
| 资助项目 | National Marine 863 Project[2013AA092902] ; National Marine 863 Project[2012AA092105] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[41506187] ; Natural Science Foundation of China[81302692] ; Natural Science Foundation of China[41476063] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM1501ZZ-03] ; SKLDR/SIMM Projects[CASIMM0120152039] ; Chinese Academy of Sciences[2016258] ; China Association for Science and Technology[00000000] ; Syngenta-SIMM-PhD Studentship Project[00000000] ; Hungarian National Research Foundation[OTKA K105871] ; National Information Infrastructure Development Institute[NIIFI 10038] ; National Excellence Program - Elaborating[4.2.4. A/2-11-1-2012-0001] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000384043800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275884]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Debrecen, Dept Organ Chem, POB 20, H-4010 Debrecen, Hungary; 3.Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England; 4.Sun Yat Sen Univ, Inst Biol Sci, Xin Gang West Rd 135, Guangzhou 510275, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Zhen-Fang,Kurtan, Tibor,Mandi, Attila,et al. Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Zhou, Zhen-Fang.,Kurtan, Tibor.,Mandi, Attila.,Gu, Yu-Cheng.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2016).Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig.SCIENTIFIC REPORTS,6. |
| MLA | Zhou, Zhen-Fang,et al."Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：上海药物研究所
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