Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer
文献类型：期刊论文
| 作者 | Zeng, Hanlin; Qu, Jia; Jin, Nan; Xu, Jun; Lin, Chenchu; Chen, Yi ; Yang, Xinying; He, Xiang; Tang, Shuai; Lan, Xiaojing
|
| 刊名 | CANCER CELL
 |
| 出版日期 | 2016-09-12 |
| 卷号 | 30期号:3页码:459-473 |
| ISSN号 | 1535-6108 |
| DOI | 10.1016/j.ccell.2016.08.001 |
| 文献子类 | Article |
| 英文摘要 | Histone deacetylase (HDAC) inhibitors have demonstrated clinical benefits in subtypes of hematological malignancies. However, the efficacy of HDAC inhibitors in solid tumors remains uncertain. This study takes breast cancer as a model to understand mechanisms accounting for limited response of HDAC inhibitors in solid tumors and to seek combination solutions. We discover that feedback activation of leukemia inhibitory factor receptor (LIFR) signaling in breast cancer limits the response to HDAC inhibition. Mechanistically, HDAC inhibition increases histone acetylation at the LIFR gene promoter, which recruits bromodomain protein BRD4, upregulates LIFR expression, and activates JAK1-STAT3 signaling. Importantly, JAK1 or BRD4 inhibition sensitizes breast cancer to HDAC inhibitors, implicating combination inhibition of HDAC with JAK1 or BRD4 as potential therapies for breast cancer. |
| WOS关键词 | PHASE-II TRIAL ; CONFERS RESISTANCE ; TUMOR XENOGRAFTS ; CONSTITUTIVE ACTIVATION ; SIGNALING PATHWAYS ; MULTIPLE-MYELOMA ; CELL LYMPHOMA ; STAT3 ; CYTOKINE ; APOPTOSIS |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000383314200011 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275893]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Huang, Min; Ding, Jian; Geng, Meiyu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Hanlin,Qu, Jia,Jin, Nan,et al. Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer[J]. CANCER CELL,2016,30(3):459-473. |
| APA | Zeng, Hanlin.,Qu, Jia.,Jin, Nan.,Xu, Jun.,Lin, Chenchu.,...&Geng, Meiyu.(2016).Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer.CANCER CELL,30(3),459-473. |
| MLA | Zeng, Hanlin,et al."Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer".CANCER CELL 30.3(2016):459-473. |
入库方式： OAI收割
来源：上海药物研究所
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