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Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade Enhanced Cancer Photodynamic Immunotherapy
文献类型：期刊论文
| 作者 | Wang, Dangge2,3,4; Wang, Tingting2,3,4; Liu, Jianping2,3; Yu, Haijun2,3 ; Jiao, Shi1; Feng, Bing2,3,4; Zhou, Fangyuan2,3; Fu, Yuanlei2,3; Yin, Qi2,3; Zhang, Pengcheng2,3
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| 刊名 | NANO LETTERS
 |
| 出版日期 | 2016-09 |
| 卷号 | 16期号:9页码:5503-5513 |
| 关键词 | Micelleplexes acid-activatable photodynamic therapy cancer immunotherapy RNA interference |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.6b01994 |
| 文献子类 | Article |
| 英文摘要 | Photodynamic therapy (PDT) has emerged as a promising clinical modality for cancer therapy due to its ability to initiate an antitumor immune response. However, PDT-mediated cancer immunotherapy is severely impaired by tumor-cell immunosuppression of host T cell antitumor activity through the programmed cell death 1 ligand (PD-L1) and programmed cell death receptor 1 (PD-1) (PD-L1PD-1) immune checkpoint pathway. Here, we demonstrate that PDT-mediated cancer immunotherapy can be augmented by PD-L1 knockdown (KD) in tumor cells. We rationally designed a versatile micelleplex by integrating an acid-activatable cationic micelle, photosensitizer (PS), and small interfering RNA (siRNA). The micelleplex was inert at physiological pH conditions and activated only upon internalization in the acidic endocytic vesicles of tumor cells for fluorescence imaging and PDT. Compared to PDT alone, the combination of PDT and PD-L1 KD showed significantly enhanced efficacy for inhibiting tumor growth and distant metastasis in a B16-F10 melanoma xenograft tumor model. These results suggest that acid-activatable micelleplexes utilizing PDT-induced cancer immunotherapy are more effective when combined with siRNA-mediated PD-L1 blockade. This study could provide a general strategy for enhancing the therapy efficacy of photodynamic cancer therapy. |
| WOS关键词 | HEAT-SHOCK PROTEINS ; FACTOR-KAPPA-B ; BREAST-CANCER ; ANTITUMOR IMMUNITY ; GENE DELIVERY ; THERAPY ; TUMORS ; CELLS ; COMBINATION ; NANOPARTICLES |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[81373359] ; National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[81521005] ; Youth Innovation Promotion Association CAS[2014248] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000383412100029 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275913]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Dangge,Wang, Tingting,Liu, Jianping,et al. Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade Enhanced Cancer Photodynamic Immunotherapy[J]. NANO LETTERS,2016,16(9):5503-5513. |
| APA | Wang, Dangge.,Wang, Tingting.,Liu, Jianping.,Yu, Haijun.,Jiao, Shi.,...&Li, Yaping.(2016).Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade Enhanced Cancer Photodynamic Immunotherapy.NANO LETTERS,16(9),5503-5513. |
| MLA | Wang, Dangge,et al."Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade Enhanced Cancer Photodynamic Immunotherapy".NANO LETTERS 16.9(2016):5503-5513. |
入库方式： OAI收割
来源：上海药物研究所
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