Asymmetric Reformatsky-Type Reaction of Isatin-Derived N-Sulfinyl Ketimines: Efficient and Practical Synthesis of Enantiopure Chiral 2-Oxoindolinyl-(3,3)-Amino Esters
文献类型：期刊论文
| 作者 | Su, Lin; Xu, Ming-Hua
|
| 刊名 | SYNTHESIS-STUTTGART
 |
| 出版日期 | 2016-08 |
| 卷号 | 48期号:16页码:2595-2602 |
| ISSN号 | 0039-7881 |
| 关键词 | asymmetric synthesis -amino acids ketimine oxoindole Reformatsky reaction chiral auxiliary AG-041R |
| DOI | 10.1055/s-0035-1561426 |
| 文献子类 | Article |
| 英文摘要 | Optically pure 2-oxoindolinyl-(3,3)-amino esters were obtained in good yields via highly efficient diastereoselective asymmetric Reformatsky-type reaction of isatin-derived chiral N-sulfinyl ketimines. The method is practical and allows rapid access to various important synthetic intermediates such as N-free 2-oxoindolinyl-(3,3)-amino acid, spiro--lactam, and hexahydrofurano[2,3-b]indole. It can also be used for the synthesis of gastrin/cholecyctokinin-B receptor antagonist AG-041R. |
| WOS关键词 | TERT-BUTANESULFINYL KETIMINES ; BETA-AMINO ACIDS ; RECEPTOR ANTAGONIST AG-041R ; QUATERNARY 3-AMINOOXINDOLES ; STEREOSELECTIVE-SYNTHESIS ; GENE DELIVERY ; IMINES ; PEPTIDES ; GASTRIN ; AMIDES |
| 资助项目 | National Natural Science Foundation of China[21325209] ; Program of Shanghai Academic Research Leader[14XD1404400] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | GEORG THIEME VERLAG KG |
| WOS记录号 | WOS:000382509100007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275936]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xu, Ming-Hua |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Lin,Xu, Ming-Hua. Asymmetric Reformatsky-Type Reaction of Isatin-Derived N-Sulfinyl Ketimines: Efficient and Practical Synthesis of Enantiopure Chiral 2-Oxoindolinyl-(3,3)-Amino Esters[J]. SYNTHESIS-STUTTGART,2016,48(16):2595-2602. |
| APA | Su, Lin,&Xu, Ming-Hua.(2016).Asymmetric Reformatsky-Type Reaction of Isatin-Derived N-Sulfinyl Ketimines: Efficient and Practical Synthesis of Enantiopure Chiral 2-Oxoindolinyl-(3,3)-Amino Esters.SYNTHESIS-STUTTGART,48(16),2595-2602. |
| MLA | Su, Lin,et al."Asymmetric Reformatsky-Type Reaction of Isatin-Derived N-Sulfinyl Ketimines: Efficient and Practical Synthesis of Enantiopure Chiral 2-Oxoindolinyl-(3,3)-Amino Esters".SYNTHESIS-STUTTGART 48.16(2016):2595-2602. |
入库方式： OAI收割
来源：上海药物研究所
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