Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula
文献类型：期刊论文
| 作者 | Zhou, Bin2; Wu, Yan2; Dalal, Seema1,3; Cassera, Maria B.1,3; Yue, Jian-Min2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2016-08 |
| 卷号 | 79期号:8页码:1952-1961 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.6b00205 |
| 文献子类 | Article |
| 英文摘要 | Aqueous ethanol extracts of powdered twigs of Euphorbia esula afforded 16 new diterpenoids, named euphorbesulins A-P. These euphorbesulins included presegetane (1-3), jatrophane (4-14), paraliane (15), and isopimarane (16) diterpenoids as well as six known analogues. Compounds 1-3 represent a rare type of presegetane diterpenoid. Their structures were determined by analysis of the spectroscopic data, and the absolute configuration of 1 was established by X-ray crystallography. Diterpenoid 7 showed low nanomolar antimalarial activity, while the remaining compounds showed only moderate or no antimalarial activity. |
| WOS关键词 | MULTIDRUG-RESISTANCE ; MACROCYCLIC DITERPENOIDS ; JATROPHANE DITERPENOIDS ; PARALIAS ; ESTERS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000382274700006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275937]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Virginia Tech, Ctr Drug Discovery, MC 0308, Blacksburg, VA 24061 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.Virginia Tech, Dept Biochem, Blacksburg, VA 24061 USA; |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Wu, Yan,Dalal, Seema,et al. Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(8):1952-1961. |
| APA | Zhou, Bin,Wu, Yan,Dalal, Seema,Cassera, Maria B.,&Yue, Jian-Min.(2016).Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula.JOURNAL OF NATURAL PRODUCTS,79(8),1952-1961. |
| MLA | Zhou, Bin,et al."Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula".JOURNAL OF NATURAL PRODUCTS 79.8(2016):1952-1961. |
入库方式： OAI收割
来源：上海药物研究所
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