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Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer
文献类型：期刊论文
| 作者 | Cao, Haiqiang1,2,3; Dan, Zhaoling1,2; He, Xinyu1,2,3; Zhang, Zhiwen1,2 ; Yu, Haijun1,2; Yin, Qi1,2; Li, Yaping1,2
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| 刊名 | ACS NANO
 |
| 出版日期 | 2016-08 |
| 卷号 | 10期号:8页码:7738-7748 |
| 关键词 | macrophage liposome drug delivery metastasis breast cancer |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.6b03148 |
| 文献子类 | Article |
| 英文摘要 | Cancer metastasis leads to high mortality of breast cancer and is difficult to treat because of the poor delivery efficiency of drugs. Herein, we report the wrapping of a drug-carrying liposome with an isolated macrophage membrane to improve delivery to metastatic sites. The macrophage membrane decoration increased cellular uptake of the emtansine liposome in metastatic 4T1 breast cancer cells and had inhibitory effects on cell viability. In vivo, the macrophage membrane enabled the liposome to target metastatic cells and produced a notable inhibitory effect on lung metastasis of breast cancer. Our results provide a biomimetic strategy via the biological properties of macrophages to enhance the medical performance of a nanoparticle in vivo for treating cancer metastasis. |
| WOS关键词 | MICROENVIRONMENTAL REGULATION ; POLYMERIC NANOPARTICLES ; TUMOR PENETRATION ; DRUG-DELIVERY ; THERAPY ; VCAM-1 ; PROGRESSION ; PLATFORM ; BIOLOGY ; GROWTH |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81521005] ; K.C. Wong Education Foundation[00000000] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000381959100057 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275938]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Haiqiang,Dan, Zhaoling,He, Xinyu,et al. Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer[J]. ACS NANO,2016,10(8):7738-7748. |
| APA | Cao, Haiqiang.,Dan, Zhaoling.,He, Xinyu.,Zhang, Zhiwen.,Yu, Haijun.,...&Li, Yaping.(2016).Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer.ACS NANO,10(8),7738-7748. |
| MLA | Cao, Haiqiang,et al."Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer".ACS NANO 10.8(2016):7738-7748. |
入库方式： OAI收割
来源：上海药物研究所
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