Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against A beta(25-35)-induced neuronal damage
文献类型：期刊论文
| 作者 | Chen, Jing2 ; Tao, Ling-Xue3; Xiao, Wei1; Ji, Sha-Sha4; Wang, Jian-Rong2; Li, Xu-Wen2; Zhang, Hai-Yan3; Guo, Yue-Wei2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2016-08-01 |
| 卷号 | 26期号:15页码:3765-3769 |
| 关键词 | Oxazino-indoles Oxa-Pictet-Spengler reaction Neuroprotective agent Alzheimer's disease SAR |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2016.05.061 |
| 文献子类 | Article |
| 英文摘要 | A series of chiral oxazino-indoles have been synthesized via a key intermolecular oxa-Pictet-Spengler reaction. These compounds exhibited significant and selective neuroprotective effects against A beta(25-35)-induced neuronal damage. This is the first report of evaluating the influence of chiral diversity of oxazino-indoles on their neuroprotective activities, with the structure-activity relationship been analyzed. The highly active compounds 3f, 3g, 4g, 4h, and 6b all performed over 90% cell protection, providing a new direction for the development of neuroprotective agents against Alzheimer's disease. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | AMYLOID PRECURSOR PROTEIN ; ALZHEIMERS-DISEASE ; NATURAL-PRODUCTS ; CASCADE REACTION ; AGGREGATION ; FUNCTIONALIZATION ; CYCLIZATION ; INHIBITION |
| 资助项目 | National Marine "863" Projects[2013AA092902] ; National Marine "863" Projects[2012AA092105] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[41476063] ; Natural Science Foundation of China[81522045] ; NSFC Shangdong Joint Fund for Marine Science Research Centers[U1406402] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM1203ZZ-03] ; SKLDR/SIMM Projects[1501ZZ-03] ; Hungarian National Research Foundation[OTKA K105871] ; Chinese Academy of Sciences[2016258] ; China Association for Science and Technology[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000380574100074 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275942]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 药物安全性评价中心 |
| 通讯作者 | Li, Xu-Wen; Zhang, Hai-Yan; Guo, Yue-Wei |
| 作者单位 | 1.Jiangsu Kanion Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Beijing 100864, Peoples R China; 4.Weifang Med Univ, Sch Biol Sci & Technol, 7166 Bao Tong West St, Weifang 261053, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jing,Tao, Ling-Xue,Xiao, Wei,et al. Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against A beta(25-35)-induced neuronal damage[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(15):3765-3769. |
| APA | Chen, Jing.,Tao, Ling-Xue.,Xiao, Wei.,Ji, Sha-Sha.,Wang, Jian-Rong.,...&Guo, Yue-Wei.(2016).Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against A beta(25-35)-induced neuronal damage.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(15),3765-3769. |
| MLA | Chen, Jing,et al."Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against A beta(25-35)-induced neuronal damage".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.15(2016):3765-3769. |
入库方式： OAI收割
来源：上海药物研究所
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