Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study
文献类型：期刊论文
| 作者 | Jia, Jingying1,3; Liu, Gangyi1,3; Zhang, Mengqi1,3; Lu, Youli1,3; Lu, Chuan1,3; Liu, Yun1,3; Zheng, Hongcao4; Wang, Wei4; Gui, Yuzhou1,2; Yu, Chen1,3 |
| 刊名 | BIOMEDICAL CHROMATOGRAPHY
 |
| 出版日期 | 2016-08 |
| 卷号 | 30期号:8页码:1291-1296 |
| 关键词 | sulcardine sulfate anti-arrhythmic agent pharmacokinetics liquid chromatography-tandem mass spectrometry bioanalytical method |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.3681 |
| 文献子类 | Article |
| 英文摘要 | Sulcardine sulfate (Sul), a novel antiarrhythmic agent, is currently in phase I and phase II clinical trials. To elucidate its clinical pharmacokinetic characteristics, a rapid and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantification of Sul in human plasma. Plasma samples were precipitated by acetonitrile and isotope-labeled sulcardine was added as internal standard. The analysis was carried out on a Capcell Pak C-18 MG III column (100x2.0mm, 5m) with 0.1% formic acid in acetonitrile solution and water (17:83, v/v) as mobile phase. The linear range was 5.0-1000ng/mL for Sul, with a lower limit of quantification of 5.0ng/mL. The intra- and inter-batch CVs were within +/- 11.0% and the accuracies were 4.9-107.3%. Our method, for the first time, allows the rapid (only 3.0min) and accurate quantification of Sul in human plasma. The method has been successfully applied in the pharmacokinetic study of Sul in a clinical trial following oral administration of Sul to healthy volunteers. Copyright (c) 2016 John Wiley & Sons, Ltd. |
| 资助项目 | Youth Talent Cultivation Plan Foundation of Xuhui District[RCKT201205] ; Ministry of Science and Technology of China[2010ZX09502-003] ; Shanghai Committee of Science and Technology, China[15DZ2291800] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000379971200018 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275946]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yiping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Clin Ctr, 966 Middle Huaihai Rd, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Xuhui Cent Hosp, Cent Lab, 966 Middle Huaihai Rd, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, Shanghai Xuhui Cent Hosp, Dept Cardiol, 966 Middle Huaihai Rd, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Jingying,Liu, Gangyi,Zhang, Mengqi,et al. Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study[J]. BIOMEDICAL CHROMATOGRAPHY,2016,30(8):1291-1296. |
| APA | Jia, Jingying.,Liu, Gangyi.,Zhang, Mengqi.,Lu, Youli.,Lu, Chuan.,...&Wang, Yiping.(2016).Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study.BIOMEDICAL CHROMATOGRAPHY,30(8),1291-1296. |
| MLA | Jia, Jingying,et al."Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study".BIOMEDICAL CHROMATOGRAPHY 30.8(2016):1291-1296. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。