Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro
文献类型：期刊论文
| 作者 | Sun, Hui-ping1,2,3; Su, Jing-han1; Meng, Qing-shuo1; Yin, Qi1 ; Zhang, Zhi-wen1; Yu, Hai-jun1; Zhang, Peng-cheng1; Wang, Si-ling1; Li, Ya-ping2,3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2016-07 |
| 卷号 | 37期号:7页码:941-949 |
| 关键词 | breast cancer 4T1 mammalian breast cancer cells metastasis nanoparticles silibinin photothermal therapy NIR laser irradiation |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2016.20 |
| 文献子类 | Article |
| 英文摘要 | Aim: To improve the therapeutic efficacy of cancer treatments, combinational therapies based on nanosized drug delivery system (NDDS) has been developed recently. In this study we designed a new NDDS loaded with an anti-metastatic drug silibinin and a photothermal agent indocyanine green (ICG), and investigated its effects on the growth and metastasis of breast cancer cells in vitro. Methods: Silibinin and ICG were self-assembled into PCL lipid nanoparticles (SIPNs). Their physical characteristics including the particle size, zeta potential, morphology and in vitro drug release were examined. 4T1 mammalian breast cancer cells were used to evaluate their cellular internalization, cytotoxicity, and their influences on wound healing, in vitro cell migration and invasion. Results: SIPNs showed a well-defined spherical shape with averaged size of 126.3 +/- 0.4 nm and zeta potential of -10.3 +/- 0.2 mV. NIR laser irradiation substantially increased the in vitro release of silibinin from the SIPNs (58.3% at the first 8 h, and 97.8% for the total release). Furthermore, NIR laser irradiation markedly increased the uptake of SIPNs into 4T1 cells. Under the NIR laser irradiation, both SIPNs and IPNs (PCL lipid nanoparticles loaded with ICG alone) caused dose-dependent ablation of 4T1 cells. The wound healing, migration and invasion experiments showed that SIPNs exposed to NIR laser irradiation exhibited dramatic in vitro anti-metastasis effects. Conclusion: SIPNs show temperature-sensitive drug release following NIR laser irradiation, which can inhibit the growth and metastasis of breast cancer cells in vitro. |
| WOS关键词 | COMBINATION THERAPY ; POLYMERIC MICELLES ; GOLD NANORODS ; DOXORUBICIN ; RELEASE ; NANOMEDICINE ; NANOCARRIER ; PACLITAXEL ; INVASION ; DELIVERY |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Basic Research Program of China[2012CB932502] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81270047] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000379430900009 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275970]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Si-ling; Li, Ya-ping |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Hui-ping,Su, Jing-han,Meng, Qing-shuo,et al. Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro[J]. ACTA PHARMACOLOGICA SINICA,2016,37(7):941-949. |
| APA | Sun, Hui-ping.,Su, Jing-han.,Meng, Qing-shuo.,Yin, Qi.,Zhang, Zhi-wen.,...&Li, Ya-ping.(2016).Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro.ACTA PHARMACOLOGICA SINICA,37(7),941-949. |
| MLA | Sun, Hui-ping,et al."Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro".ACTA PHARMACOLOGICA SINICA 37.7(2016):941-949. |
入库方式： OAI收割
来源：上海药物研究所
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