Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury
文献类型：期刊论文
| 作者 | Chen, Weimin2; Li, Shanshan2; Li, Jinwei2; Zhou, Wen2; Wu, Shouhai2; Xu, Shengmei2; Cui, Ke2; Zhang, Donna D.1; Liu, Bo2,3 |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2016-07 |
| 卷号 | 30期号:7页码:2500-2510 |
| 关键词 | Nrf2 activator Keap1-Nrf2 pathway oxidative damage |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.201500109R |
| 文献子类 | Article |
| 英文摘要 | The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial regulator of the cellular antioxidant response and xenobiotic metabolism. Activation of the Nrf2 signaling pathway has been demonstrated to confer protection against environmental insults and prevent disease or inhibit the progression of diseases related to oxidative stress. In an attempt to identify novel improved Nrf2 inducers for systemic protection against tissue damage by environmental insults, we identified art emisitene as a novel Nrf2 activator using antioxidant responsive element luciferase assay in MDA-MB-231 cells. Further studies suggest that art emisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability. In Nrf2 wild-type mice, systemic administration of artemisitene strongly inhibits bleomycin-induced lung damage. Artemisitene represents a novel class of Nrf2 inducer, and artemisitene-based therapeutic approach targeting Nrf2 may also provide antioxidant protection for humans against tissue damage by toxic chemicals. |
| WOS关键词 | NRF2-KEAP1 SIGNALING PATHWAY ; TRANSCRIPTION FACTOR NRF2 ; CANCER CHEMOPREVENTION ; OXIDATIVE STRESS ; KEAP1 ; MECHANISM ; FIBROSIS ; SYSTEM ; LIGASE ; MICE |
| 资助项目 | National Natural Science Foundation of China[81473294] ; National Natural Science Foundation of China[81202398] ; Chinese Ministry of Science and Technology[2013CB966902] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000379249500006 |
| 出版者 | FEDERATION AMER SOC EXP BIOL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275973]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Chen, Weimin |
| 作者单位 | 1.Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ USA; 2.Guangdong Prov Acad Chinese Med Sci, Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Weimin,Li, Shanshan,Li, Jinwei,et al. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury[J]. FASEB JOURNAL,2016,30(7):2500-2510. |
| APA | Chen, Weimin.,Li, Shanshan.,Li, Jinwei.,Zhou, Wen.,Wu, Shouhai.,...&Liu, Bo.(2016).Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury.FASEB JOURNAL,30(7),2500-2510. |
| MLA | Chen, Weimin,et al."Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury".FASEB JOURNAL 30.7(2016):2500-2510. |
入库方式： OAI收割
来源：上海药物研究所
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