Synthesis and decreasing A beta content evaluation of arctigenin-4-yl carbamate derivatives
文献类型：期刊论文
| 作者 | Xu, Xingyu1; Li, Cong2; Lei, Min1 ; Zhu, Zhiyuan1; Yan, Jianming1; Shen, Xu1,2; Hu, Lihong1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 26期号:13页码:2988-2991 |
| 关键词 | Arctigenin (ATG) Natural product Arctigenin-4-yl 3-carbamate Structure-activity relationships (SARs) Alzheimer's disease (AD) |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2016.05.028 |
| 文献子类 | Article |
| 英文摘要 | A series of arctigenin-4-yl carbamate derivatives were synthesized and evaluated for potency in reducing beta-amyloid (A beta) content in HEK293-APPswe cells. Most of the arctigenin-4-yl aralkyl or aryl carbamate derivatives showed improved potency in reducing A beta content. Among the synthesized compounds, arctigenin-4-yl (3-chlorophenyl)carbamate (20) exhibited the strongest potency with 78.7% A beta content reduction at 20 mu M. Furthermore, the effect of arctigenin-4-yl (4-chlorophenyl)carbamate (19) and arctigenin-4-yl (3-chlorophenyl)carbamate (20) on lowing A beta content was better than arctigenin under the concentrations of 1, 10 and 20 mu M. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PHENYLPROPANOID DIBENZYLBUTYROLACTONE LIGNAN ; ALZHEIMERS-DISEASE ; NEURONS ; POTENT ; CELLS ; RATS |
| 资助项目 | National Natural Science Foundation of China[81473110] ; Shanghai Science & Technology Support Program[13431900401] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000377470600004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275978]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lei, Min; Shen, Xu; Hu, Lihong |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shanghai Univ, Sch Life Sci, 99 Shangda Rd, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xingyu,Li, Cong,Lei, Min,et al. Synthesis and decreasing A beta content evaluation of arctigenin-4-yl carbamate derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(13):2988-2991. |
| APA | Xu, Xingyu.,Li, Cong.,Lei, Min.,Zhu, Zhiyuan.,Yan, Jianming.,...&Hu, Lihong.(2016).Synthesis and decreasing A beta content evaluation of arctigenin-4-yl carbamate derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(13),2988-2991. |
| MLA | Xu, Xingyu,et al."Synthesis and decreasing A beta content evaluation of arctigenin-4-yl carbamate derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.13(2016):2988-2991. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。