Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting
文献类型：期刊论文
| 作者 | Yuan, Zhize4; Li, Haiqing4; Qi, Quan4; Gong, Wenhui4; Qian, Cheng1; Dong, Rong1; Zang, Yi2 ; Li, Jia2,3; Zhou, Mi4; Cai, Junfeng4
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-06-17 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep28221 |
| 文献子类 | Article |
| 英文摘要 | Growth differentiation factor-15 (GDF-15) has recently emerged as a risk predictor in patients with cardiovascular diseases. We therefore aimed to investigate the role of GDF-15 in the occurrence of cardiac injury during off-pump coronary artery bypass grafting (OPCAB). 55 consecutive patients with coronary artery diseases were recruited in this prospective, observational study. All patients were operated for OPCAB surgery. Serial blood samples were collected preoperatively, 12 hours and 36 hours after surgery. GDF-15, together with C-reactive protein, cardiac troponin I, creatine kinase MB and N-terminal pro B-type natriuretic peptide levels in plasma were measured at each time-point. GDF-15 levels increased significantly at 12 hours after surgery, attaining nearly 2.5 times the baseline levels (p < 0.001). Postoperative GDF-15 levels correlated positively with cTnI (p = 0.003) and EuroSCORE II (p = 0.013). According to the ROC curves, postoperative plasma GDF-15 was found to be the best biomarker to predict perioperative cardiac injury, compared with cTnI, CK-MB and EuroSCORE II. Circulating GDF-15 is a promising novel biomarker for identifying perioperative myocardial injury in patients undergoing OPCAB. |
| WOS关键词 | CARDIAC TROPONIN-I ; TGF-BETA SUPERFAMILY ; HEART-FAILURE ; RISK STRATIFICATION ; BIOCHEMICAL MARKERS ; SURGERY ; INFARCTION ; ELEVATION ; REVASCULARIZATION ; MORTALITY |
| 资助项目 | National Natural Science Foundation of China[81200093] ; National Natural Science Foundation of China[81571826] ; National Natural Science Foundation of China[31330029] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000392076000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275994]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Ye, Xiaofeng; Zhao, Qiang |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Anesthesiol, Ruijin Er Rd 197, Shanghai 200025, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.East China Normal Univ, Inst Adv Interdisciplinary Res, North Zhongshan Rd Campus 3663 N Zhongshan Rd, Shanghai 200062, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Cardiac Surg, Ruijin Er Rd 197, Shanghai 200025, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yuan, Zhize,Li, Haiqing,Qi, Quan,et al. Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Yuan, Zhize.,Li, Haiqing.,Qi, Quan.,Gong, Wenhui.,Qian, Cheng.,...&Zhao, Qiang.(2016).Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting.SCIENTIFIC REPORTS,6. |
| MLA | Yuan, Zhize,et al."Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：上海药物研究所
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