Advances in development of fluorescent probes for detecting amyloid-beta aggregates
文献类型：期刊论文
| 作者 | Xu, Ming-ming1; Ren, Wen-ming2; Tang, Xi-can1 ; Hu, You-hong2; Zhang, Hai-yan1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2016-06 |
| 卷号 | 37期号:6页码:719-730 |
| 关键词 | Alzheimer's disease diagnostic biomarker amyloid-beta optical imaging near-infrared fluorescent probes |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2015.155 |
| 文献子类 | Review |
| 英文摘要 | With accumulating evidence suggesting that amyloid-beta (A beta) deposition is a good diagnostic biomarker for Alzheimer's disease (AD), the discovery of active A beta probes has become an active area of research. Among the existing imaging methods, optical imaging targeting A beta aggregates (fibrils or oligomers), especially using near-infrared (NIR) fluorescent probes, is increasingly recognized as a promising approach for the early diagnosis of AD due to its real time detection, low cost, lack of radioactive exposure and high-resolution. In the past decade, a variety of fluorescent probes have been developed and tested for efficiency in vitro, and several probes have shown efficacy in AD transgenic mice. This review classifies these representative probes based on their chemical structures and functional modes (dominant solvent-dependent mode and a novel solvent-independent mode). Moreover, the pharmaceutical characteristics of these representative probes are summarized and discussed. This review provides important perspectives for the future development of novel NIR A beta diagnostic probes. |
| WOS关键词 | SPORADIC ALZHEIMERS-DISEASE ; IN-VIVO DETECTION ; MOLECULAR IMAGING PROBES ; COGNITIVE DECLINE ; CROSS-LINKING ; MOUSE-BRAIN ; PLAQUES ; DEPOSITION ; CURCUMIN ; LOAD |
| 资助项目 | National Natural Science Foundation of China[81522045] ; National Natural Science Foundation of China[81225022] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5722047 |
| WOS记录号 | WOS:000377281000001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276020]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Hu, You-hong; Zhang, Hai-yan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ming-ming,Ren, Wen-ming,Tang, Xi-can,et al. Advances in development of fluorescent probes for detecting amyloid-beta aggregates[J]. ACTA PHARMACOLOGICA SINICA,2016,37(6):719-730. |
| APA | Xu, Ming-ming,Ren, Wen-ming,Tang, Xi-can,Hu, You-hong,&Zhang, Hai-yan.(2016).Advances in development of fluorescent probes for detecting amyloid-beta aggregates.ACTA PHARMACOLOGICA SINICA,37(6),719-730. |
| MLA | Xu, Ming-ming,et al."Advances in development of fluorescent probes for detecting amyloid-beta aggregates".ACTA PHARMACOLOGICA SINICA 37.6(2016):719-730. |
入库方式： OAI收割
来源：上海药物研究所
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