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Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity

文献类型：期刊论文

作者Yao, Sheng2,3,4; To, Kenneth Kin-Wah3,4,5; Ma, Liang2,3,4; Yin, Chun1,3,4; Tang, Chunping2,3,4; Chai, Stella1,3,4; Ke, Chang-Qiang2,3,4; Lin, Ge1,3,4; Ye, Yang2,3,4,6
刊名PHYTOCHEMISTRY
出版日期2016-06
卷号126页码:47-58
关键词Marsdenia tenacissima Asclepiadaceae C-21 steroids Open-chain sugars Absolute configuration X-ray crystallography diffraction Chemoresistance reversal activity Structure elucidation
ISSN号0031-9422
DOI10.1016/j.phytochem.2016.03.006
文献子类Article
英文摘要A polyoxypregnane aglycone,12 beta-O-acetyl-11 alpha-O-isobutyryltenacigenin B, and four polyoxypregnane glycosides with a pachybionic acid ester moiety, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandronyl)-11 alpha-O-isobutylyltenacigenin B, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandrony1)-11 alpha-O-tigloyltenacigenin B, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandronyl)-11 alpha-O-2-methylbutylyltenacigenin B, and 12 beta-O-acetyl-3-O-glucopyranosyl-(1 -> 4)-6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-D-oleandronyl)-11 alpha-O-tigloyltenacigenin B, were isolated from the canes of Marsdenia tenacissima, together with a disaccharide derivative. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations were further determined by X-ray crystallographic analysis. With the exception of the disaccharide derivative, all five compounds are unusual naturally occurring polyoxypregnane glycosides bearing an open-chain sugar moiety. Two of these exhibit a wide spectrum of chemoresistance reversal activity, and potential mechanisms were studied accordingly. (C) 2016 Elsevier Ltd. All rights reserved.
WOS关键词GLYKOSIDE UND AGLYKONE ; MULTIDRUG-RESISTANCE ; PREGNANE GLYCOSIDES ; PERIPLOCA-SEPIUM ; DIE GLYKOSIDE ; CANCER CELLS ; OLIGOSACCHARIDES ; STEMS ; OVEREXPRESSION ; CYTOTOXICITY
资助项目National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Natural Science Funds of China[81302657] ; Ministry of Science and Technology[2010DFA30980] ; Chinese Academy of Sciences[KSZD-EW-Z-004-01] ; Youth Innovation Promotion Association CAS[00000000] ; Shanghai Commission of Science and Technology[11DZ1970700] ; Shanghai Commission of Science and Technology[12JC1410300] ; Health and Medical Research Fund (HHSRF Project) from the Food and Health Bureau, HKSAR[08090481] ; Chinese University of Hong Kong[2008.1.079] ; One-off Funding for Joint Lab/Research Collaboration from CUHK[00000000] ; Seed Fund for Joint Establishments from CUHK School of Biomedical Science, CUHK[00000000]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000375166600006
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276032]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Lin, Ge; Ye, Yang
作者单位1.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Chem, State Key Lab Drug Res & Nat Prod, 555 Zu Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Joint Res Lab Promoting Globalizat Tradit Chinese, Beijing 100864, Peoples R China;
4.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China;
5.Chinese Univ Hong Kong, Fac Med, Sch Pharm, Hong Kong, Hong Kong, Peoples R China;
6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Yao, Sheng,To, Kenneth Kin-Wah,Ma, Liang,et al. Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity[J]. PHYTOCHEMISTRY,2016,126:47-58.
APA Yao, Sheng.,To, Kenneth Kin-Wah.,Ma, Liang.,Yin, Chun.,Tang, Chunping.,...&Ye, Yang.(2016).Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity.PHYTOCHEMISTRY,126,47-58.
MLA Yao, Sheng,et al."Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity".PHYTOCHEMISTRY 126(2016):47-58.

入库方式： OAI收割

来源：上海药物研究所

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