Rhodium-catalyzed asymmetric intramolecular addition of arylboronic acids to ketones: catalytic enantioselective access to 3-hydroxy-2,3-dihydrobenzofurans bearing a tetrasubstituted carbon stereocenter
文献类型：期刊论文
| 作者 | Zhu, Dong-Xing; Chen, Wen-Wen ; Xu, Ming-Hua
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2016-05-26 |
| 卷号 | 72期号:21页码:2637-2642 |
| 关键词 | Rhodium Asymmetric catalysis Intramolecular addition Sulfur-olefin ligand Dihydrobenzofuran |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2015.04.030 |
| 文献子类 | Article |
| 英文摘要 | A highly enantioselective rhodium-catalyzed intramolecular addition of arylboronic acids to unactivated ketones has been developed. By employing a simple, chiral sulfur-based branched olefin as the ligand, the reaction occurs efficiently under mild conditions. A wide range of chiral 3-hydroxy-2,3-dihydrobenzofurans bearing a tetrasubstituted stereocenter at C-3 position can be obtained in high yields (up to 98%) with excellent enantiomeric excesses (up to 98% ee). (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ALPHA-KETOESTERS ; TRANS-INFLUENCE ; OLEFIN LIGANDS ; COUMARINS ; HYDROGENATION ; 1,2-ADDITION ; DERIVATIVES ; ALCOHOLS ; ANALOGS ; COMPLEX |
| 资助项目 | National Natural Science Foundation of China[21325209] ; National Natural Science Foundation of China[21472205] ; Shanghai Municipal Committee of Science and Technology[14XD1404400] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000375812400007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276037]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xu, Ming-Hua |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Dong-Xing,Chen, Wen-Wen,Xu, Ming-Hua. Rhodium-catalyzed asymmetric intramolecular addition of arylboronic acids to ketones: catalytic enantioselective access to 3-hydroxy-2,3-dihydrobenzofurans bearing a tetrasubstituted carbon stereocenter[J]. TETRAHEDRON,2016,72(21):2637-2642. |
| APA | Zhu, Dong-Xing,Chen, Wen-Wen,&Xu, Ming-Hua.(2016).Rhodium-catalyzed asymmetric intramolecular addition of arylboronic acids to ketones: catalytic enantioselective access to 3-hydroxy-2,3-dihydrobenzofurans bearing a tetrasubstituted carbon stereocenter.TETRAHEDRON,72(21),2637-2642. |
| MLA | Zhu, Dong-Xing,et al."Rhodium-catalyzed asymmetric intramolecular addition of arylboronic acids to ketones: catalytic enantioselective access to 3-hydroxy-2,3-dihydrobenzofurans bearing a tetrasubstituted carbon stereocenter".TETRAHEDRON 72.21(2016):2637-2642. |
入库方式： OAI收割
来源：上海药物研究所
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