Design and synthesis of novel triazole derivatives containing gamma-lactam as potential antifungal agents
文献类型：期刊论文
| 作者 | Xu, Yuan-Yuan2; Qian, An-Ran2; Cao, Xu-Feng2; Ling, Chen-Yu2; Cao, Yong-Bing1; Wang, Rui-Lian1; Li, Yi-Su3; Yang, Yu-She2
|
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2016-05 |
| 卷号 | 27期号:5页码:703-706 |
| 关键词 | Synthesis Triazole gamma-Lactam Antifungal activity |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2016.01.040 |
| 文献子类 | Article |
| 英文摘要 | A series of novel triazole derivatives containing gamma-lactam were designed and synthesized, and their structures were confirmed by H-1 NMR, C-13 NMR and HRMS. The in vitro antifungal activities of the target compounds were evaluated. The results showed that all of the compounds exhibited stronger activity against the six clinically important fungi tested than fiuconazole. 3D and 3E showed comparative activity against the fungi tested except for Candida glabrata and Aspergillus fumigates as voriconazole. In addition, the docking model for 2A and CYP51 was investigated. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | FUNGAL-INFECTIONS ; WATER SOLUBILITY ; DRUG-RESISTANCE ; 3-SUBSTITUTED-4(3H)-QUINAZOLINONES ; MECHANISMS ; PATHOGEN |
| 资助项目 | National Natural Science Foundation of China[21402223] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5717491 |
| WOS记录号 | WOS:000377325900019 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276047]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yu-She |
| 作者单位 | 1.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yuan-Yuan,Qian, An-Ran,Cao, Xu-Feng,et al. Design and synthesis of novel triazole derivatives containing gamma-lactam as potential antifungal agents[J]. CHINESE CHEMICAL LETTERS,2016,27(5):703-706. |
| APA | Xu, Yuan-Yuan.,Qian, An-Ran.,Cao, Xu-Feng.,Ling, Chen-Yu.,Cao, Yong-Bing.,...&Yang, Yu-She.(2016).Design and synthesis of novel triazole derivatives containing gamma-lactam as potential antifungal agents.CHINESE CHEMICAL LETTERS,27(5),703-706. |
| MLA | Xu, Yuan-Yuan,et al."Design and synthesis of novel triazole derivatives containing gamma-lactam as potential antifungal agents".CHINESE CHEMICAL LETTERS 27.5(2016):703-706. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。