Biginkgosides A-I, Unexpected Minor Dimeric Flavonol Diglycosidic Truxinate and Truxillate Esters from Ginkgo biloba Leaves and Their Antineuroinflammatory and Neuroprotective Activities
文献类型：期刊论文
| 作者 | Ma, Guang-Lei2; Xiong, Juan2; Yang, Guo-Xun2; Pan, Li-Long3; Hu, Chang-Ling2; Wang, Wei1; Fan, Hui4; Zhao, Qiu-Hua4; Zhang, Hai-Yan1 ; Hu, Jin-Feng2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2016-05 |
| 卷号 | 79期号:5页码:1354-1364 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.6b00061 |
| 文献子类 | Article |
| 英文摘要 | Nine unexpected new flavonol glycoside cyclodimers in the truxinate (1-7, biginkgosides A G, respectively) or trwdllate [biginkgosides H (8) and I (9)] forms were isolated as minor components from the extract of Ginkgo biloba leaves. The new dimers possess an unusual cyclobutane ring formed by a [2+2]-cycloaddition between two symmetric (for compounds 1-5 and 7-9) or nonsymmetric (for 6) flavonol coumaroyl glucorhamnosides. A plausible biosynthetic pathway for these new compounds based on the frontier molecular orbital theory of cycloaddition reactions is briefly discussed. An antineuroinflammatory screening revealed that biginkgosides E (5) and H (8) inhibited nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells, with IC50 values of 2.91 and 17.23 mu M, respectively. Additionally, biginkgoside F (6) showed a significant neuroprotective effect (34.3% increase in cell viability at 1 mu M) against A beta(25-35)-induced cell viability decrease in SH-SY5Y neuroblastoma cells. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; ANTI-NEUROINFLAMMATORY ACTIVITIES ; ACID-DERIVATIVES ; NEURODEGENERATIVE DISEASE ; PARKINSONS-DISEASE ; ALZHEIMERS-DISEASE ; CINNAMIC ACID ; INFLAMMATION ; PHOTODIMERS ; GLYCOSIDES |
| 资助项目 | NSFC[21472021] ; NSFC[81273401] ; NSFC[81202420] ; NSFC[21402052] ; National Basic Research Program of China (973 Program)[2013CB530700] ; STCSM[11DZ1921203] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000377150900017 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276051]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Qiu-Hua; Zhang, Hai-Yan; Hu, Jin-Feng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 3.Fudan Univ, Sch Pharm, Dept Pharmacol, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 4.E China Normal Univ, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Guang-Lei,Xiong, Juan,Yang, Guo-Xun,et al. Biginkgosides A-I, Unexpected Minor Dimeric Flavonol Diglycosidic Truxinate and Truxillate Esters from Ginkgo biloba Leaves and Their Antineuroinflammatory and Neuroprotective Activities[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(5):1354-1364. |
| APA | Ma, Guang-Lei.,Xiong, Juan.,Yang, Guo-Xun.,Pan, Li-Long.,Hu, Chang-Ling.,...&Hu, Jin-Feng.(2016).Biginkgosides A-I, Unexpected Minor Dimeric Flavonol Diglycosidic Truxinate and Truxillate Esters from Ginkgo biloba Leaves and Their Antineuroinflammatory and Neuroprotective Activities.JOURNAL OF NATURAL PRODUCTS,79(5),1354-1364. |
| MLA | Ma, Guang-Lei,et al."Biginkgosides A-I, Unexpected Minor Dimeric Flavonol Diglycosidic Truxinate and Truxillate Esters from Ginkgo biloba Leaves and Their Antineuroinflammatory and Neuroprotective Activities".JOURNAL OF NATURAL PRODUCTS 79.5(2016):1354-1364. |
入库方式： OAI收割
来源：上海药物研究所
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